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Mutanofactin promotes adhesion and biofilm formation of cariogenic Streptococcus mutans
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Journal Article
Mutanofactin promotes adhesion and biofilm formation of cariogenic Streptococcus mutans
2021
Overview
Cariogenic
Streptococcus mutans
is known as a predominant etiological agent of dental caries due to its exceptional capacity to form biofilms. From strains of
S. mutans
isolated from dental plaque, we discovered, in the present study, a polyketide/nonribosomal peptide biosynthetic gene cluster,
muf
, which directly correlates with a strong biofilm-forming capability. We then identified the
muf
-associated bioactive product, mutanofactin-697, which contains a new molecular scaffold, along with its biosynthetic logic. Further mode-of-action studies revealed that mutanofactin-697 binds to
S. mutans
cells and also extracellular DNA, increases bacterial hydrophobicity, and promotes bacterial adhesion and subsequent biofilm formation. Our findings provided an example of a microbial secondary metabolite promoting biofilm formation via a physicochemical approach, highlighting the importance of secondary metabolism in mediating critical processes related to the development of dental caries.
The mutanofactin family of lipopeptide natural products, produced by strains of cariogenic
Streptococcus mutans
, promotes biofilm formation via increased cell-surface hydrophobicity and binding to extracellular DNA.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Adhesion
/ Bacterial Adhesion - drug effects
/ Biofilms
/ Biofilms - growth & development
/ Biological Factors - biosynthesis
/ Biological Factors - isolation & purification
/ Biological Factors - pharmacology
/ Chemistry and Materials Science
/ Computational Biology - methods
/ Dental Caries - microbiology
/ DNA
/ Etiology
/ Gene Expression Regulation, Bacterial
/ Humans
/ Hydrophobic and Hydrophilic Interactions
/ Peptide Biosynthesis, Nucleic Acid-Independent
/ Secondary Metabolism - genetics
/ Streptococcus mutans - genetics
/ Streptococcus mutans - growth & development
