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Parahippocampal Corpora Amylacea
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Journal Article
Parahippocampal Corpora Amylacea
2010
Overview
Corpora amylacea (CA) normally accumulate within perivascular, subpial, and subependymal astrocytic processes. CA are associated with a number of conditions including normal aging, hippocampal sclerosis associated with temporal lobe epilepsy, multiple sclerosis, Lafora-type progressive myoclonic epilepsy, and adult polyglucosan body disease. Reports of massive localized accumulation of CA in the brain outside of these conditions are rare.
A 49-year-old woman, with a long-standing history of migraine headaches, presented to her primary care provider for increased headache duration. Brain magnetic resonance imaging (MRI) revealed a left parahippocampal lesion, suggestive of low-grade glioma.
Given the MRI suggestive of left parahippocampal glioma, left-sided frontotemporal craniotomy was performed for resection of the lesion. Specimens obtained during the operation revealed focal high-density accumulation of CA with no evidence of neoplasm, ischemia, or hypoxic injury.
This case illustrates the possibility that localized high-density CA accumulation can present as an intrinsic lesion on brain MRI. CA should be included in the differential diagnosis for patients presenting with brain MRI suggestive of nonenhancing space-occupying lesions.
Publisher
Lippincott Williams & Wilkins,Wolters Kluwer Health, Inc
Subject
Biological and medical sciences
/ Female
/ Glioma
/ Humans
/ Inclusion Bodies - metabolism
/ Inclusion Bodies - pathology
/ Migraine Disorders - metabolism
/ Migraine Disorders - pathology
/ NMR
/ Parahippocampal Gyrus - metabolism
/ Parahippocampal Gyrus - pathology
/ Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
