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No concomitant occurrence of the N-ras and p53 gene mutations in myelodysplastic syndromes
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No concomitant occurrence of the N-ras and p53 gene mutations in myelodysplastic syndromes
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Journal Article
No concomitant occurrence of the N-ras and p53 gene mutations in myelodysplastic syndromes
1997
Overview
Mutations of the N-ras oncogene and p53 tumor suppressor gene were simultaneously investigated in bone marrow cells from 44 patients with myelodysplastic syndrome (MDS) or MDS-derived leukemia by single-strand conformation polymorphism (SSCP) analysis followed by direct sequencing. The mutations of the N-ras gene were detected only in two cases with MDS-derived leukemia. Three patients with MDS-derived leukemia and one with refractory anemia with excess of blasts exhibited five mutations of the p53 gene. No concomitant mutations of both genes were observed in our study, suggesting that alterations of both genes could play an important role in the progression of MDS in a non-cooperative manner.
Publisher
Nature Publishing,Nature Publishing Group
Subject
/ Anemia, Refractory - genetics
/ Anemia, Refractory, with Excess of Blasts - genetics
/ Biological and medical sciences
/ Exons
/ Genes
/ Hematologic and hematopoietic diseases
/ Humans
/ Leukemia
/ Leukemia, Myelomonocytic, Chronic - genetics
/ Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
/ Mutation
/ Myelodysplastic Syndromes - genetics
/ Myelodysplastic Syndromes - immunology
/ Myelodysplastic Syndromes - pathology
/ Polymerase Chain Reaction - methods
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