Asset Details
Do you wish to reserve the book?
Selective COX-2 Inhibition Is Associated with Decreased Mucosal Damage Induced by Acid and Pepsin in Rabbit Esophagitis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Selective COX-2 Inhibition Is Associated with Decreased Mucosal Damage Induced by Acid and Pepsin in Rabbit Esophagitis
Do you wish to request the book?
Selective COX-2 Inhibition Is Associated with Decreased Mucosal Damage Induced by Acid and Pepsin in Rabbit Esophagitis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Selective COX-2 Inhibition Is Associated with Decreased Mucosal Damage Induced by Acid and Pepsin in Rabbit Esophagitis
2003
Overview
To evaluate the effects of COX-1 and/or COX-2 inhibition in a model of chronic esophagitis in rabbits.
Both high- and low-grade esophagitis were induced in rabbits by the perfusion of acidified pepsin. Rabbits were treated with either a selective COX-2 inhibitor (DFU[3-(3-Fluorophenyl)-4-(4-Methanesulfonyl)-5,5-Dimethyl-5H-Furan-2-One];30 mg/Kg/day), a nonspecific COX inhibitor (indomethacin; 2 mg/Kg/day), or a COX-1 preferential inhibitor (piroxicam; 2 mg/Kg/12 h).
Prostaglandins are derived from COX-1 activity in the normal esophagus. Both low- and high-grade esophagitis are associated with a progressive increase of COX activity, which is partially dependent on the COX-2 isoform. DFU reduced muscosal damage in both models of esophagitis. However, indomethacin did not affect significantly mucosal damage, and piroxicam increased damage in low-grade esophagitis.
COX-1 activity is constitutive in the rabbit esophageal mucosa, but both COX-2 and COX-1 activity are increased under the impact of acidified pepsin. Treatment with the COX-2 inhibitor DFU is associated with improvement of mucosal damage, which may have therapeutic implications.
Publisher
Springer Nature B.V
Subject
Acids - administration & dosage
/ Animals
/ Cyclooxygenase Inhibitors - administration & dosage
/ Cyclooxygenase Inhibitors - pharmacology
/ Esophagitis - chemically induced
/ Furans - administration & dosage
/ Indomethacin - administration & dosage
/ Pepsin A - administration & dosage
/ Piroxicam - administration & dosage
/ Prostaglandin-Endoperoxide Synthases - metabolism
/ Rabbits
