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Evidence of a Role of Tumor Necrosis Factor α in Refractory Asthma
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Evidence of a Role of Tumor Necrosis Factor α in Refractory Asthma
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Journal Article
Evidence of a Role of Tumor Necrosis Factor α in Refractory Asthma
2006
Overview
Patients with severe asthma are distinct from patients with milder forms of the disease. Peripheral-blood monocytes from patients with severe asthma were shown to have enhanced expression of markers associated with tumor necrosis factor α (TNF-α). In a pilot, placebo-controlled, crossover study, the TNF-α receptor–binding agent etanercept improved airway responsiveness and asthma-related quality of life. TNF-α may have a role in refractory asthma.
In a pilot study, the TNF-α receptor–binding agent etanercept improved airway responsiveness and asthma-related quality of life. TNF-α may have a role in refractory asthma.
The rates of death and complications are high among patients with refractory asthma and account for a disproportionate amount of the health resource burden attributed to asthma.
1
Treatment options are limited for these patients. The airway abnormality in refractory asthma differs from that in mild-to-moderate asthma in having a more heterogeneous pattern of inflammatory response,
2
with greater involvement of neutrophils
3
and the distal lung
4
and increased airway remodeling.
5
Tumor necrosis factor α (TNF-α) is a pleiotropic inflammatory cytokine expressed in increased amounts by mast cells
6
and present in increased concentrations in bronchoalveolar fluid from the airways of patients with asthma. . . .
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ Aged
/ Bronchial Hyperreactivity - drug therapy
/ Bronchial Hyperreactivity - metabolism
/ Female
/ Forced Expiratory Volume - drug effects
/ Humans
/ Immunoglobulin G - therapeutic use
/ Immunologic Factors - therapeutic use
/ Male
/ Receptors, Tumor Necrosis Factor - therapeutic use
/ Receptors, Tumor Necrosis Factor, Type I - biosynthesis
/ Tumor Necrosis Factor-alpha - antagonists & inhibitors
/ Tumor Necrosis Factor-alpha - biosynthesis
