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Solasodine inhibits human colorectal cancer cells through suppression of the AKT/glycogen synthase kinase‐3β/β‐catenin pathway
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Solasodine inhibits human colorectal cancer cells through suppression of the AKT/glycogen synthase kinase‐3β/β‐catenin pathway
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Journal Article
Solasodine inhibits human colorectal cancer cells through suppression of the AKT/glycogen synthase kinase‐3β/β‐catenin pathway
2017
Overview
Solasodine is a main active component isolated from Solanum incanum L. that performs a wide range of functions containing anti‐oxidant, anti‐infection, and neurogenesis promotion. In this study, we explored the influence of solasodine on three types of human colorectal cancer (CRC) cell lines. The results show that solasodine prohibited CRC cell proliferation dose‐ and time‐dependently and impeded CRC cell motility by downregulating MMPs. Solasodine was also found to fuel caspase‐cascade reaction and increase the ratio between Bax and Bcl‐2 so as to induce CRC cell apoptosis. When cells were pretreated with AKT activator (insulin‐like growth factor‐1) followed by solasodine, the solasodine‐induced apoptosis was partially abrogated by insulin‐like growth factor‐1. Moreover, solasodine hindered tumor development and stimulated similar mechanisms in vivo. In general, our study provides the first evidence that solasodine has a suppressive effect on CRC cells and that this agent may be a novel therapeutic drug for CRC treatment. Solasodine inhibits CRC growth in vitro and in vivo. The mechanism involves suppression of AKT/GSK‐3β/β‐catenin signaling. Solasodine could be a potential antitumor agent for CRC.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc
Subject
/ bcl-2-Associated X Protein - genetics
/ Caspase
/ Cell Movement - drug effects
/ Cell Proliferation - drug effects
/ Colorectal Neoplasms - drug therapy
/ Colorectal Neoplasms - genetics
/ Colorectal Neoplasms - pathology
/ Dose-Response Relationship, Drug
/ Gene Expression Regulation, Neoplastic - drug effects
/ Glycogen
/ Glycogen Synthase Kinase 3 beta - genetics
/ Humans
/ Insulin
/ Insulin-Like Growth Factor I - administration & dosage
/ Kinases
/ Motility
/ Original
/ Proto-Oncogene Proteins c-akt - genetics
/ Proto-Oncogene Proteins c-bcl-2 - genetics
/ R&D
/ Signal Transduction - drug effects
