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Whitening effects of 4-hydroxyphenethyl alcohol isolated from water boiled with Hizikia fusiformis
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Whitening effects of 4-hydroxyphenethyl alcohol isolated from water boiled with Hizikia fusiformis
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Journal Article
Whitening effects of 4-hydroxyphenethyl alcohol isolated from water boiled with Hizikia fusiformis
2014
Overview
Isolation of phenolic compounds from water boiled with Hizikia fusiformis and purificartrion of the extracts from solvent fractions was achieved using column chromatography. The simple phenolic compound, 4-hydroxyphenethyl alcohol (4-HPEA) with an elemental composition C8H10O2 was identified on the basis of spectroscopic data. The whitening effects of 4-HPEA, inhibitory activity against mushroom tyrosinase, and inhibitory activity against melanin production in B16 melanoma cells were evaluated using an in vitro assay system. The whitening effect of 4-HPEA was also measured using a colorimeter and visual assessment of UVB induced hyperpigmentation of brown guinea pig skin. Topical application of 4-HPEA promoted depigmentation of UVB-induced hyperpigmented spots. 4-HPEA has a potential for use as a safe and effective ingredient for whitening in cosmetic and medical applications.
Publisher
Springer Nature B.V
