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Trial of Roflumilast Cream for Chronic Plaque Psoriasis
by
Kempers, Steven E
, Lebwohl, Mark G
, Kircik, Leon H
, Trotman, Marie-Louise
, Draelos, Zoe D
, Papp, Kim A
, Zirwas, Mathew
, Smith, Kathleen
, Osborne, David W
, Gooderham, Melinda J
, Merritt, Charlotte
, Berk, David R
, Navale, Lynn
, Stein Gold, Linda
, Welgus, Howard
in
Administration, Topical
/ Adult
/ Aminopyridines - administration & dosage
/ Aminopyridines - adverse effects
/ Benzamides - administration & dosage
/ Benzamides - adverse effects
/ Clinical trials
/ Cyclopropanes - administration & dosage
/ Cyclopropanes - adverse effects
/ Cytokines
/ Double-Blind Method
/ Drug Administration Schedule
/ Enrollments
/ Erythema
/ Female
/ Humans
/ Immunoglobulin A
/ Least-Squares Analysis
/ Male
/ Middle Aged
/ Patients
/ Phosphodiesterase
/ Phosphodiesterase 4 Inhibitors - administration & dosage
/ Phosphodiesterase 4 Inhibitors - adverse effects
/ Phosphodiesterase IV
/ Psoriasis
/ Psoriasis - drug therapy
/ Severity of Illness Index
/ Skin
/ Skin Cream - administration & dosage
2020
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Trial of Roflumilast Cream for Chronic Plaque Psoriasis
by
Kempers, Steven E
, Lebwohl, Mark G
, Kircik, Leon H
, Trotman, Marie-Louise
, Draelos, Zoe D
, Papp, Kim A
, Zirwas, Mathew
, Smith, Kathleen
, Osborne, David W
, Gooderham, Melinda J
, Merritt, Charlotte
, Berk, David R
, Navale, Lynn
, Stein Gold, Linda
, Welgus, Howard
in
Administration, Topical
/ Adult
/ Aminopyridines - administration & dosage
/ Aminopyridines - adverse effects
/ Benzamides - administration & dosage
/ Benzamides - adverse effects
/ Clinical trials
/ Cyclopropanes - administration & dosage
/ Cyclopropanes - adverse effects
/ Cytokines
/ Double-Blind Method
/ Drug Administration Schedule
/ Enrollments
/ Erythema
/ Female
/ Humans
/ Immunoglobulin A
/ Least-Squares Analysis
/ Male
/ Middle Aged
/ Patients
/ Phosphodiesterase
/ Phosphodiesterase 4 Inhibitors - administration & dosage
/ Phosphodiesterase 4 Inhibitors - adverse effects
/ Phosphodiesterase IV
/ Psoriasis
/ Psoriasis - drug therapy
/ Severity of Illness Index
/ Skin
/ Skin Cream - administration & dosage
2020
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Trial of Roflumilast Cream for Chronic Plaque Psoriasis
by
Kempers, Steven E
, Lebwohl, Mark G
, Kircik, Leon H
, Trotman, Marie-Louise
, Draelos, Zoe D
, Papp, Kim A
, Zirwas, Mathew
, Smith, Kathleen
, Osborne, David W
, Gooderham, Melinda J
, Merritt, Charlotte
, Berk, David R
, Navale, Lynn
, Stein Gold, Linda
, Welgus, Howard
in
Administration, Topical
/ Adult
/ Aminopyridines - administration & dosage
/ Aminopyridines - adverse effects
/ Benzamides - administration & dosage
/ Benzamides - adverse effects
/ Clinical trials
/ Cyclopropanes - administration & dosage
/ Cyclopropanes - adverse effects
/ Cytokines
/ Double-Blind Method
/ Drug Administration Schedule
/ Enrollments
/ Erythema
/ Female
/ Humans
/ Immunoglobulin A
/ Least-Squares Analysis
/ Male
/ Middle Aged
/ Patients
/ Phosphodiesterase
/ Phosphodiesterase 4 Inhibitors - administration & dosage
/ Phosphodiesterase 4 Inhibitors - adverse effects
/ Phosphodiesterase IV
/ Psoriasis
/ Psoriasis - drug therapy
/ Severity of Illness Index
/ Skin
/ Skin Cream - administration & dosage
2020
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Journal Article
Trial of Roflumilast Cream for Chronic Plaque Psoriasis
2020
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Overview
A cream formulation of the phosphodiesterase type 4 inhibitor roflumilast, in two concentrations, led to higher percentages of patients with clearance or near-clearance of psoriatic lesions at 6 weeks than placebo. Difficult-to-treat intertriginous areas also improved as compared with placebo.
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ Aminopyridines - administration & dosage
/ Aminopyridines - adverse effects
/ Benzamides - administration & dosage
/ Benzamides - adverse effects
/ Cyclopropanes - administration & dosage
/ Cyclopropanes - adverse effects
/ Drug Administration Schedule
/ Erythema
/ Female
/ Humans
/ Male
/ Patients
/ Phosphodiesterase 4 Inhibitors - administration & dosage
/ Phosphodiesterase 4 Inhibitors - adverse effects
/ Skin
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