Asset Details
Do you wish to reserve the book?
A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention
Do you wish to request the book?
A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention
2015
Overview
Among patients with a history of skin cancer, nicotinamide treatment was associated with a 23% lower rate of new nonmelanoma (basal-cell and squamous-cell) skin cancers than placebo, resulted in 13% fewer actinic keratoses after 12 months, and had similar adverse effects.
Nonmelanoma skin cancers, mainly basal-cell carcinomas and squamous-cell carcinomas, are the most common cancers in white populations.
1
In Australia, nonmelanoma skin cancers are four times as common as all other cancers combined,
2
,
3
and in the United States, the annual total cost of treating nonmelanoma skin cancers is estimated to be $4.8 billion.
4
Basal-cell carcinomas rarely metastasize but are locally invasive and can be disfiguring.
5
Squamous-cell carcinomas, especially less well-differentiated tumors on the head and neck, have metastatic potential and may originate from premalignant actinic keratoses.
6
Nonmelanoma skin cancers and actinic keratoses are caused primarily by exposure to ultraviolet (UV) . . .
Publisher
Massachusetts Medical Society
Subject
/ Aged
/ Carcinoma, Basal Cell - epidemiology
/ Carcinoma, Basal Cell - prevention & control
/ Carcinoma, Squamous Cell - epidemiology
/ Carcinoma, Squamous Cell - prevention & control
/ DNA
/ Female
/ Humans
/ Keratosis, Actinic - epidemiology
/ Keratosis, Actinic - prevention & control
/ Male
/ Niacinamide - adverse effects
/ Niacinamide - therapeutic use
/ Skin Neoplasms - epidemiology
/ Skin Neoplasms - prevention & control
