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Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis

by Furie, Richard A. , Omachi, Theodore A. , Tumlin, James A. , Garg, Jay P. , Rovin, Brad H. , Raghu, Harini , Yoo, Bongin , Pendergraft, William F. , Navarro Sandoval, Cleyber , Santiago, Mittermayer B. , Irazoque Palazuelos, Fedra , Martins, Elsa , Alvarez, Damaris , Lila, Alexander M. , Zuta Santillán, Adolfina Elizabeth , Kirchner, Petra , Malvar, Ana , Sehgal, Himanshi , Ross Terres, Jorge , Hassan, Imran , Saxena, Amit , Schindler, Thomas , Aroca-Martínez, Gustavo

in Adult / Allergy / Antibodies, Monoclonal, Humanized - administration & dosage / Antibodies, Monoclonal, Humanized - adverse effects / Antibodies, Monoclonal, Humanized - pharmacokinetics / Autoimmune Disease / Biopsy / CD20 antigen / Chronic illnesses / Coronaviruses / COVID-19 / Creatinine / Creatinine - urine / Dose-Response Relationship, Drug / Double-Blind Method / Drug Administration Schedule / Drug Therapy, Combination - adverse effects / Drug Therapy, Combination - methods / Female / Gastroenteritis - epidemiology / Gastroenteritis - immunology / Glomerular Disease / Glomerular Filtration Rate / Humans / Immunology / Immunosuppressive Agents - administration & dosage / Immunosuppressive Agents - adverse effects / Immunosuppressive Agents - pharmacokinetics / Infusions, Intravenous / Kidney diseases / Kidneys / Lupus / Lupus nephritis / Lupus Nephritis - diagnosis / Lupus Nephritis - drug therapy / Lupus Nephritis - immunology / Lupus Nephritis - urine / Male / Monoclonal antibodies / Mycophenolate mofetil / Mycophenolic acid / Mycophenolic Acid - administration & dosage / Mycophenolic Acid - adverse effects / Nephrology / Placebos / Pneumonia - epidemiology / Pneumonia - immunology / Prednisone / Prednisone - administration & dosage / Prednisone - adverse effects / Proteins / Proteinuria - diagnosis / Proteinuria - drug therapy / Proteinuria - urine / Rheumatology / Rheumatology General / Treatment Outcome / Urinary Tract Infections - epidemiology / Urinary Tract Infections - immunology / Young Adult

2025

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Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis

2025

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Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis

2025

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Journal Article

Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis

Furie, Richard A.,

Omachi, Theodore A.,

Tumlin, James A.,

Garg, Jay P.,

Rovin, Brad H.,

Raghu, Harini,

Yoo, Bongin,

Pendergraft, William F.,

Navarro Sandoval, Cleyber,

Santiago, Mittermayer B.,

Irazoque Palazuelos, Fedra,

Martins, Elsa,

Alvarez, Damaris,

Lila, Alexander M.,

Zuta Santillán, Adolfina Elizabeth,

Kirchner, Petra,

Malvar, Ana,

Sehgal, Himanshi,

Ross Terres, Jorge,

Hassan, Imran,

Saxena, Amit,

Schindler, Thomas,

Aroca-Martínez, Gustavo

2025

Overview

In this trial, obinutuzumab, a humanized type II anti-CD20 monoclonal antibody, plus standard therapy provided significantly better renal responses than standard therapy alone in patients with lupus nephritis.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Allergy

/ Antibodies, Monoclonal, Humanized - administration & dosage

/ Antibodies, Monoclonal, Humanized - adverse effects

/ Antibodies, Monoclonal, Humanized - pharmacokinetics

/ Autoimmune Disease

/ Biopsy