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Graft-versus-Host Disease Prophylaxis with Cyclophosphamide and Cyclosporin

by Koldej, Rachel M. , De Abreu Lourenco, Richard , Stubbs, John , Morrissey, C. Orla , Patil, Sushrut S. , Arenas, Andrea , Lewis, Clinton , Wong, Eric , Ritchie, David S. , Yeung, David T. , Perera, Travis , Gottlieb, David J. , Curtis, David J. , Moore, John , Tey, Siok-Keen , Munsef, Nadia , Hill, Geoffrey R. , Reynolds, John , Purtill, Duncan

in Adult / Aged / Allergy / Allografts / Autoimmune Disease / Bone marrow / Bone Marrow Transplantation / Calcineurin inhibitors / Calcineurin Inhibitors - administration & dosage / Calcineurin Inhibitors - adverse effects / Clinical trials / Cost analysis / Cyclophosphamide / Cyclophosphamide - administration & dosage / Cyclophosphamide - adverse effects / Cyclosporine - administration & dosage / Cyclosporine - adverse effects / Cytomegalovirus / Disease prevention / Disease-Free Survival / Drug Therapy, Combination / Female / Graft versus host disease / Graft vs Host Disease - epidemiology / Graft vs Host Disease - mortality / Graft vs Host Disease - prevention & control / Graft-versus-host reaction / Hematologic Neoplasms - mortality / Hematologic Neoplasms - therapy / Hematological diseases / Hematology / Humans / Immunology / Immunosuppressive Agents - administration & dosage / Immunosuppressive Agents - adverse effects / Kaplan-Meier Estimate / Leukemia / Lymphoma / Male / Medical research / Methotrexate / Methotrexate - adverse effects / Methotrexate - therapeutic use / Middle Aged / Neoplasm Recurrence, Local - epidemiology / Neoplasm Recurrence, Local - prevention & control / Oncology / Patients / Peripheral blood / Peripheral Blood Stem Cell Transplantation - adverse effects / Remission (Medicine) / Stem cell transplantation / Stem cells / Transplantation Conditioning - methods / Transplantation, Homologous - adverse effects / Transplantation, Homologous - methods / Transplants & implants / Treatments in Oncology

2025

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Graft-versus-Host Disease Prophylaxis with Cyclophosphamide and Cyclosporin

2025

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2025

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Journal Article

Graft-versus-Host Disease Prophylaxis with Cyclophosphamide and Cyclosporin

Koldej, Rachel M.,

De Abreu Lourenco, Richard,

Stubbs, John,

Morrissey, C. Orla,

Patil, Sushrut S.,

Arenas, Andrea,

Lewis, Clinton,

Wong, Eric,

Ritchie, David S.,

Yeung, David T.,

Perera, Travis,

Gottlieb, David J.,

Curtis, David J.,

Moore, John,

Tey, Siok-Keen,

Munsef, Nadia,

Hill, Geoffrey R.,

Reynolds, John,

Purtill, Duncan

2025

Overview

Among patients undergoing stem-cell transplantation from matched related donors, cyclophosphamide plus cyclosporin led to significantly longer GVHD-free, relapse-free survival than standard prophylaxis.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Aged

/ Allergy

/ Allografts

/ Autoimmune Disease

/ Bone marrow

/ Bone Marrow Transplantation