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Design, synthesis, and fungicidal activity evaluation of 2-methyl-5-phenylthiazole-4-carboxamides bearing morpholine, thiomorpholine, or thiomorpholine 1,1-dioxide moiety
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Design, synthesis, and fungicidal activity evaluation of 2-methyl-5-phenylthiazole-4-carboxamides bearing morpholine, thiomorpholine, or thiomorpholine 1,1-dioxide moiety
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Design, synthesis, and fungicidal activity evaluation of 2-methyl-5-phenylthiazole-4-carboxamides bearing morpholine, thiomorpholine, or thiomorpholine 1,1-dioxide moiety
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Journal Article
Design, synthesis, and fungicidal activity evaluation of 2-methyl-5-phenylthiazole-4-carboxamides bearing morpholine, thiomorpholine, or thiomorpholine 1,1-dioxide moiety
2024
Overview
A series of 2-methyl-5-phenylthiazole derivatives were designed, synthesized, and characterized by
1
H,
13
C NMR spectra and HRMS. Subsequently, their antifungal activity was evaluated, and the bioassay results showed that almost all title compounds possess potential fungicidal activity against
B. cinerea
. [5-(4-Chlorophenyl)-2-methylthiazol-4-yl](morpholin-4-yl)methanone and {2-methyl-5-[4-(tri-fluoromethyl)phenyl]thiazol-4-yl}(thiomorpholin-4-yl)methanone displayed EC
50
values of 19.6 mg/l and 15.6 mg/l respectively, against
B. cinerea
, showing higher potency than that of hymexazol.
Publisher
Springer US,Springer,Springer Nature B.V
Subject
