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Genome-Wide Sequence Analysis of Kaposi Sarcoma-Associated Herpesvirus Shows Diversification Driven by Recombination

by Whitby, Denise , Sallah, Neneh , Asiki, Gershim , Palser, Anne L , Newton, Robert , Kellam, Paul , Labo, Nazzarena , Watson, Simon J , Marshall, Vickie , Barroso, Inês

in Adolescent / Adult / Aged / Aged, 80 and over / Cohort Studies / DNA, Viral - genetics / Female / Genome-Wide Association Study / Genomics - methods / Herpesvirus 8, Human - genetics / Humans / Major and Brief Reports / Male / Middle Aged / Recombination, Genetic - genetics / Sarcoma, Kaposi - virology / Sequence Analysis, DNA / Uganda / Young Adult

2018

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Genome-Wide Sequence Analysis of Kaposi Sarcoma-Associated Herpesvirus Shows Diversification Driven by Recombination

by Whitby, Denise , Sallah, Neneh , Asiki, Gershim , Palser, Anne L , Newton, Robert , Kellam, Paul , Labo, Nazzarena , Watson, Simon J , Marshall, Vickie , Barroso, Inês

2018

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Genome-Wide Sequence Analysis of Kaposi Sarcoma-Associated Herpesvirus Shows Diversification Driven by Recombination

by Whitby, Denise , Sallah, Neneh , Asiki, Gershim , Palser, Anne L , Newton, Robert , Kellam, Paul , Labo, Nazzarena , Watson, Simon J , Marshall, Vickie , Barroso, Inês

2018

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Journal Article

Genome-Wide Sequence Analysis of Kaposi Sarcoma-Associated Herpesvirus Shows Diversification Driven by Recombination

Whitby, Denise,

Sallah, Neneh,

Asiki, Gershim,

Palser, Anne L,

Newton, Robert,

Kellam, Paul,

Labo, Nazzarena,

Watson, Simon J,

Marshall, Vickie,

Barroso, Inês

2018

Overview

This study presents 45 new KSHV genomes sequenced from Uganda, a KSHV endemic region. We present new evidence for the presence of inter- and intragenic recombination across genomes contributing to the diversification of KSHV strains into at least 5 types.

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Publisher

Oxford University Press

Subject

Adolescent

/ Adult

/ Aged

/ Aged, 80 and over

/ Cohort Studies

/ DNA, Viral - genetics

/ Female