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Translating the Genomic Revolution — Targeted Genome Editing in Primates
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Journal Article
Translating the Genomic Revolution — Targeted Genome Editing in Primates
2014
Overview
New methods involving DNA-cutting enzymes guided by precisely tailored DNA-binding elements are increasingly used in the laboratory and are potential tools for gene therapy in humans.
The promise of the genomics revolution is appealing, ambitious, and multipronged. Should this promise be delivered on, patients, equipped with interpretations of their genomes, will be able to gauge the risk of receiving a diagnosis of cancer or heart disease. Physicians will be able to quickly pinpoint the genetic basis of a disorder and take appropriate actions to treat the disease using specific “genome editing” tools. Moving the field one step closer to realizing this promise, Niu et al.
1
and Liu at al.
2
recently reported the use of designer enzymes (called endonucleases) to introduce specific changes into the genome of . . .
Publisher
Massachusetts Medical Society
