Asset Details
Do you wish to reserve the book?
Structural and functional brain alterations in subthreshold depression: A multimodal coordinate‐based meta‐analysis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Structural and functional brain alterations in subthreshold depression: A multimodal coordinate‐based meta‐analysis
Do you wish to request the book?
Structural and functional brain alterations in subthreshold depression: A multimodal coordinate‐based meta‐analysis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Structural and functional brain alterations in subthreshold depression: A multimodal coordinate‐based meta‐analysis
2024
Overview
Imaging studies of subthreshold depression (StD) have reported structural and functional abnormalities in a variety of spatially diverse brain regions. However, there is no consensus among different studies. In the present study, we applied a multimodal meta‐analytic approach, the Activation Likelihood Estimation (ALE), to test the hypothesis that StD exhibits spatially convergent structural and functional brain abnormalities compared to healthy controls. A total of 31 articles with 25 experiments were included, collectively representing 1001 subjects with StD. We found consistent differences between StD and healthy controls mainly in the left insula across studies with various neuroimaging methods. Further exploratory analyses found structural atrophy and decreased functional activities in the right pallidum and thalamus in StD, and abnormal spontaneous activity converged to the middle frontal gyrus. Coordinate‐based meta‐analysis found spatially convergent structural and functional impairments in StD. These findings provide novel insights for understanding the neural underpinnings of subthreshold depression and enlighten the potential targets for its early screening and therapeutic interventions in the future. Subthreshold depression is a threatening precursor and risk factor for major depressive disorder. CBMA found spatially convergent structural and functional impairments in subthreshold depression mainly in the left insula. And abnormal spontaneous brain activity converged to the middle frontal gyrus in subthreshold depression.
Publisher
John Wiley & Sons, Inc
