Journal Article

Tannenbaum and metal stents in the palliative treatment of malignant distal bile duct obstruction: a comparative study of patency and cost effectiveness

Chatzimavroudis, G., Zavos, C., Papaziogas, B., Paroutoglou, G., Gatopoulou, A., Beltsis, A., Katsinelos, P., Moschos, I., Kountouras, J., Paikos, D.

2006

Overview

Stent clogging is the major limitation of palliative treatment for malignant biliary obstruction. Metal stents have much better patency than plastic stents, but are more expensive. Preliminary data suggest that the recently designed plastic (Tannenbaum) stent has better duration of patency than the polyethylene stent. This study aimed to compare the efficacy and cost effectiveness between the Tannenbaum stent without side holes and the uncovered metal stent for patients with malignant distal common bile duct obstruction. In this study, 47 patients (median age, 73 years, range, 56-86 years) with inoperable malignant distal common bile duct strictures were prospectively randomized to receive either a Tannenbaum stent (n = 24) or an uncovered self-expandable metal stent (n = 23). The patients were clinically evaluated, and biochemical tests were analyzed if necessary until their death or surgery for gastric outlet obstruction. Cumulative first stent patency and patient survival were compared between the two groups. Cost-effectiveness analysis also was performed for the two study groups. The two groups were comparable in terms of age, gender, and diagnosis. The median first stent patency was longer in the metal group than in the Tannenbaum stent group (255 vs 123.5 days; p = 0.002). There was no significant difference in survival between the two groups. The total cost associated with the Tannenbaum stents was lower than for the metal stents (17,700 vs 30,100 euros; p = 0.001), especially for patients with liver metastases (3,000 vs 6,900 euros; p < 0.001). Metal stent placement is an effective treatment for inoperable malignant distal common bile duct obstruction, but Tannenbaum stent placement is a cost-saving strategy, as compared with metal stent placement, especially for patients with liver metastases and expected short survival time.

• Publisher: Springer,Springer Nature B.V
• Subject: Aged / Aged, 80 and over / Bile Duct Neoplasms - complications / Bile Duct Neoplasms - economics / Bile Duct Neoplasms - mortality / Biological and medical sciences / Cholestasis, Extrahepatic - economics / Cholestasis, Extrahepatic - etiology / Cholestasis, Extrahepatic - therapy / Common Bile Duct Diseases - economics / Common Bile Duct Diseases - etiology / Common Bile Duct Diseases - therapy / Cost-Benefit Analysis / Digestive system / Female / Humans / Investigative techniques, diagnostic techniques (general aspects) / Male / Medical sciences / Metals / Middle Aged / Palliative Care / Pancreatic Neoplasms - complications / Pancreatic Neoplasms - economics / Pancreatic Neoplasms - mortality / Radiodiagnosis. Nmr imagery. Nmr spectrometry / Stents - adverse effects / Stents - economics / Survival Rate