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Zika Virus Associated with Microcephaly

by Korva, Misa , Tul, Nataša , Fabjan Vodušek, Vesna , Pižem, Jože , Petrovec, Miroslav , Popović, Mara , Kolenc, Marko , Vesnaver Vipotnik, Tina , Avšič Županc, Tatjana , Poljšak-Prijatelj, Mateja , Vizjak, Alenka , Mlakar, Jernej , Resman Rus, Katarina , Mraz, Jerica

in Abortion, Therapeutic / Adult / Autopsy / Birth defects / Brain / Brain - embryology / Brain - pathology / Brain - virology / Cortex / Electron microscopy / Female / Fetal Diseases - diagnostic imaging / Fetal Diseases - pathology / Fetal Diseases - virology / Fetuses / Genome, Viral / Genomes / Gestation / Humans / Hydrocephalus / Infectious Disease Transmission, Vertical / Maternal & child health / Microcephaly - diagnostic imaging / Microcephaly - pathology / Microcephaly - virology / Microencephaly / Neurological disorders / Phylogeny / Placenta / Polymerase chain reaction / Pregnancy / Pregnancy Trimester, Third / Reverse Transcriptase Polymerase Chain Reaction / Substantia alba / Ultrasonography, Prenatal / Ultrasound / Viral infections / Zika virus / Zika Virus - genetics / Zika Virus - isolation & purification / Zika Virus Infection - complications / Zika Virus Infection - pathology / Zika Virus Infection - transmission

2016

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Zika Virus Associated with Microcephaly

2016

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2016

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Journal Article

Zika Virus Associated with Microcephaly

Korva, Misa,

Tul, Nataša,

Fabjan Vodušek, Vesna,

Pižem, Jože,

Petrovec, Miroslav,

Popović, Mara,

Kolenc, Marko,

Vesnaver Vipotnik, Tina,

Avšič Županc, Tatjana,

Poljšak-Prijatelj, Mateja,

Vizjak, Alenka,

Mlakar, Jernej,

Resman Rus, Katarina,

Mraz, Jerica

2016

Overview

Zika virus is an emerging infectious disease that is spreading rapidly through the Americas. A major concern is the association with birth defects, especially microcephaly. This report shows evidence of Zika virus in the fetal brain. ZIKV, an emerging mosquito-borne flavivirus, was initially isolated from a rhesus monkey in the Zika forest in Uganda in 1947. 1 It is transmitted by various species of aedes mosquitoes. After the first human ZIKV infection, sporadic cases were reported in Southeast Asia and sub-Saharan Africa. 2 ZIKV was responsible for the outbreak in Yap Island of Micronesia in 2007 and for major epidemics in French Polynesia, New Caledonia, the Cook Islands, and Easter Island in 2013 and 2014. 3 , 4 In 2015, there was a dramatic increase in reports of ZIKV infection in the Americas. Brazil is the most affected country, with . . .

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Publisher

Massachusetts Medical Society

Subject

Abortion, Therapeutic

/ Adult

/ Autopsy

/ Birth defects

/ Brain

/ Brain - embryology

/ Brain - pathology