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Efficacy and Safety of an Ad26.RSV.preF–RSV preF Protein Vaccine in Older Adults

by Douoguih, Macaya , Ervin, John , Chan, Eric K.H. , Sadoff, Jerald , Vandenberghe, Sjouke , Bart, Stephan , Callendret, Benoit , De Paepe, Els , Comeaux, Christy A. , Heijnen, Esther , Gymnopoulou, Efi , Falsey, Ann R. , Williams, Kristi , Bastian, Arangassery R. , Menten, Joris

in Adverse events / Age / Aged / Aging / Aging General / Antibodies, Neutralizing - blood / Antibodies, Neutralizing - immunology / Antibodies, Viral - blood / Antibodies, Viral - immunology / Coronaviruses / COVID-19 / Disease prevention / Double-Blind Method / Double-blind studies / Enzymes / FDA approval / Geriatrics / Global Health / Humans / Immunogenicity / Immunogenicity, Vaccine - immunology / Infections / Infectious Disease / Infectious Disease General / Older people / Participation / Placebos / Proteins / Respiratory syncytial virus / Respiratory Syncytial Virus Infections - blood / Respiratory Syncytial Virus Infections - immunology / Respiratory Syncytial Virus Infections - prevention & control / Respiratory Syncytial Virus Vaccines - adverse effects / Respiratory Syncytial Virus Vaccines - therapeutic use / Respiratory Syncytial Virus, Human - immunology / Respiratory tract diseases / Respiratory Tract Infections - blood / Respiratory Tract Infections - immunology / Respiratory Tract Infections - prevention & control / Treatment Outcome / Vaccine Efficacy / Vaccines / Viral Infections

2023

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Efficacy and Safety of an Ad26.RSV.preF–RSV preF Protein Vaccine in Older Adults

2023

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Efficacy and Safety of an Ad26.RSV.preF–RSV preF Protein Vaccine in Older Adults

2023

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Journal Article

Efficacy and Safety of an Ad26.RSV.preF–RSV preF Protein Vaccine in Older Adults

Douoguih, Macaya,

Ervin, John,

Chan, Eric K.H.,

Sadoff, Jerald,

Vandenberghe, Sjouke,

Bart, Stephan,

Callendret, Benoit,

De Paepe, Els,

Comeaux, Christy A.,

Heijnen, Esther,

Gymnopoulou, Efi,

Falsey, Ann R.,

Williams, Kristi,

Bastian, Arangassery R.,

Menten, Joris

2023

Overview

A combination of adenovirus 26 and protein vaccines was used to deliver a prefusion stabilized RSV protein. RSV-related lower respiratory tract illness developed in fewer vaccine recipients than placebo recipients.

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Publisher

Massachusetts Medical Society

Subject

Adverse events

/ Age

/ Aged

/ Aging

/ Aging General

/ Antibodies, Neutralizing - blood

/ Antibodies, Neutralizing - immunology