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A Randomized Trial of Progesterone in Women with Recurrent Miscarriages

by Briley, Annette L , Mol, Ben W , Ross, Jackie A , Regan, Lesley , Truchanowicz, Ewa , Stewart, Jane , Brady, Rebecca , Koot, Yvonne E.M , Goddijn, Mariette , Li, Tin-Chiu , Dawood, Feroza , Cavallaro, Rebecca , Chu, Justin J , Khalaf, Yacoub , Hoek, Annemieke , Koks, Carolien A.M , Moore, Judith , Kilby, Mark D , Coomarasamy, Arri , Ewies, Ayman , Sharpe, Lisa , Cheong, Ying C , Rai, Rajendra , MacLean, Marjory , Kaaijk, Eugenie M , Eapen, Abey , Farquharson, Roy G , Gupta, Pratima , Vaithilingam, Nirmala , Quenby, Siobhan , Williams, Helen , Seed, Paul T , Bloemenkamp, Kitty W.M , Small, Rachel , Bender Atik, Ruth

in Abortion, Habitual - prevention & control / Administration, Intravaginal / Adult / Body Mass Index / Double-Blind Method / Drug therapy / Evidence-based medicine / Female / Gestation / Gestational Age / Humans / Live Birth / Miscarriage / Motivation / Pregnancy / Pregnancy Trimester, First / Progesterone / Progesterone - therapeutic use / Supplements / Treatment Failure / Vagina

2015

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A Randomized Trial of Progesterone in Women with Recurrent Miscarriages

2015

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2015

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Journal Article

A Randomized Trial of Progesterone in Women with Recurrent Miscarriages

Briley, Annette L,

Mol, Ben W,

Ross, Jackie A,

Regan, Lesley,

Truchanowicz, Ewa,

Stewart, Jane,

Brady, Rebecca,

Koot, Yvonne E.M,

Goddijn, Mariette,

Li, Tin-Chiu,

Dawood, Feroza,

Cavallaro, Rebecca,

Chu, Justin J,

Khalaf, Yacoub,

Hoek, Annemieke,

Koks, Carolien A.M,

Moore, Judith,

Kilby, Mark D,

Coomarasamy, Arri,

Ewies, Ayman,

Sharpe, Lisa,

Cheong, Ying C,

Rai, Rajendra,

MacLean, Marjory,

Kaaijk, Eugenie M,

Eapen, Abey,

Farquharson, Roy G,

Gupta, Pratima,

Vaithilingam, Nirmala,

Quenby, Siobhan,

Williams, Helen,

Seed, Paul T,

Bloemenkamp, Kitty W.M,

Small, Rachel,

Bender Atik, Ruth

2015

Overview

In this multicenter, double-blind, placebo-controlled, randomized trial involving women with recurrent miscarriages, treatment with progesterone, administered vaginally during the first trimester, did not increase the rate of live births. Recurrent miscarriage, defined as the loss of three or more pregnancies, affects approximately 1% of couples who attempt to have a child. 1 Even after comprehensive investigations, a cause for recurrent miscarriage is identified in less than half of these couples. 1 , 2 Unexplained recurrent miscarriage is associated with substantial adverse clinical and psychological consequences for the women and their families. Various therapeutic strategies to increase the rate of live births among these women have been evaluated, but no effective treatment has been identified. Progesterone is essential to achieve and maintain a healthy pregnancy. It is secreted naturally by the corpus luteum . . .

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Publisher

Massachusetts Medical Society

Subject

Abortion, Habitual - prevention & control

/ Administration, Intravaginal

/ Adult

/ Body Mass Index

/ Double-Blind Method

/ Drug therapy

/ Evidence-based medicine