Asset Details
Do you wish to reserve the book?
Implications of cleaved caspase 3 and AIF expression in colorectal cancer based on patient age
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Implications of cleaved caspase 3 and AIF expression in colorectal cancer based on patient age
Do you wish to request the book?
Implications of cleaved caspase 3 and AIF expression in colorectal cancer based on patient age
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Implications of cleaved caspase 3 and AIF expression in colorectal cancer based on patient age
2012
Overview
A high incidence of colorectal cancer (CRC) has been established in the elderly population. Apoptosis is a key event in maintaining colon homeostasis, both in aging as well as in cancer prevention. Here, we report that colon morphology is affected during the aging process: crypt loss (P=0.045) and increasing distances between crypts (P=0.0001678) were observed, associated with a tendency for mucosa reduction (P=0.083). In addition, our results show that apoptosis plays a determining role on the effect of aging during CRC. Increased expression of cleaved caspase 3 (the key factor implicated in the caspase-dependent pathway; P=0.026 for non-tumor tissues, P=0.0013 for tumor tissues) and AIF (implicated in the caspase-independent pathway; P=0.037) in tissue from elderly patients has been observed. Furthermore, elderly patients respond better to chemotherapy than younger ones (P=9.27 x 10(-5)). These results suggest that patient age should be taken into account to adapt treatment of CRC.
Publisher
Spandidos,Spandidos Publications
Subject
/ Aged
/ Aging
/ Apoptosis Inducing Factor - metabolism
/ Biological and medical sciences
/ Colon
/ Colorectal Neoplasms - drug therapy
/ Colorectal Neoplasms - metabolism
/ Colorectal Neoplasms - pathology
/ Female
/ Gastroenterology. Liver. Pancreas. Abdomen
/ Humans
/ Intestinal Mucosa - metabolism
/ Intestinal Mucosa - pathology
/ Male
/ Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
/ Tumors
