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Serum Biomarkers after Traumatic and Hypoxemic Brain Injuries: Insight into the Biochemical Response of the Pediatric Brain to Inflicted Brain Injury
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Serum Biomarkers after Traumatic and Hypoxemic Brain Injuries: Insight into the Biochemical Response of the Pediatric Brain to Inflicted Brain Injury
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Serum Biomarkers after Traumatic and Hypoxemic Brain Injuries: Insight into the Biochemical Response of the Pediatric Brain to Inflicted Brain Injury
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Journal Article
Serum Biomarkers after Traumatic and Hypoxemic Brain Injuries: Insight into the Biochemical Response of the Pediatric Brain to Inflicted Brain Injury
2006
Overview
Inflicted traumatic brain injury (iTBI) involves a combination of mechanical trauma and hypoxemia. Serum biomarker concentrations may provide objective information about their relative importance to the pathophysiology of iTBI. We compared the time course of neuron-specific enolase (NSE), S100B and myelin basic protein after pediatric hypoxic-ischemic brain injury, iTBI and noninflicted TBI (nTBI). The time to reach peak concentrations of all three biomarkers was shorter after nTBI. Initial and peak S100B, initial and peak myelin basic protein and peak NSE concentrations were no different between the three groups. Initial NSE concentration was highest after nTBI. These results suggest that the biochemical response of the brain to iTBI is distinct from the response to nTBI and shares temporal similarities with hypoxic-ischemic brain injury. This may have important implications for the treatment and prognosis of children with iTBI.
Publisher
S. Karger AG
Subject
/ Brain Injuries - physiopathology
/ Child
/ Female
/ Humans
/ Hypoxia-Ischemia, Brain - blood
/ Hypoxia-Ischemia, Brain - diagnosis
/ Hypoxia-Ischemia, Brain - physiopathology
/ Infant
/ Male
/ Myelin Basic Protein - analysis
/ Myelin Basic Protein - blood
/ Nerve Growth Factors - analysis
/ Nerve Growth Factors - blood
/ Nerve Tissue Proteins - analysis
/ Nerve Tissue Proteins - blood
/ Phosphopyruvate Hydratase - analysis
/ Phosphopyruvate Hydratase - blood
ISBN
3805581653, 9783805581653
