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REPLY TO JIMÉNEZ-ALONSO ET AL., SCHOOLING AND ZHAO, AND MORTAZAVI
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REPLY TO JIMÉNEZ-ALONSO ET AL., SCHOOLING AND ZHAO, AND MORTAZAVI
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REPLY TO JIMÉNEZ-ALONSO ET AL., SCHOOLING AND ZHAO, AND MORTAZAVI
REPLY TO JIMÉNEZ-ALONSO ET AL., SCHOOLING AND ZHAO, AND MORTAZAVI
Journal Article

REPLY TO JIMÉNEZ-ALONSO ET AL., SCHOOLING AND ZHAO, AND MORTAZAVI

2018
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Overview
Palmer et al comments on the criticisms of their study exploring the relationship between thymic involution and rising disease incidence with age. There are experiments from the 1970s in which athymic mice are measured to have similar cancer risk to normal mice, while having increased risk of infectious diseases. Furthermore, individuals with DiGeorge syndrome often have thymus problems and a higher risk of infectious diseases, yet some reports find that they have similar cancer risk. On the other hand, there are experiments in which thymectomized mice displayed a higher cancer risk and others in which thymus grafts on nude mice induce cancer remission. In addition, there is an association between low T cell receptor excision circles (a by-product of T cell production) and certain cancers, and a perspective study found that short leukocyte telomeres predict cancer risk. They stresses that their article provide statistical support for thymic T cell output strongly influencing cancer incidence.