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Optimal care and survival for signet-ring cell and non-signet-ring cell gastric cancer are more achievable at academic cancer centers
by
Farma, Jeffrey M.
, Deng, Mengying
, Handorf, Elizabeth
, Greco, Stephanie H.
, Moslim, Maitham A.
in
Academic
/ Academic Medical Centers - standards
/ Academic Medical Centers - statistics & numerical data
/ Adult
/ Aged
/ Aged, 80 and over
/ Cancer
/ Cancer therapies
/ Carcinoma, Signet Ring Cell - mortality
/ Carcinoma, Signet Ring Cell - surgery
/ Cell survival
/ Chemotherapy
/ Community centers
/ Comprehensive cancer center
/ Dissection
/ Female
/ Gastrectomy
/ Gastric cancer
/ Gastrointestinal surgery
/ Humans
/ Lymph nodes
/ Lymphatic system
/ Male
/ Middle Aged
/ Mortality
/ Patients
/ Population studies
/ Quality of Health Care
/ Retrospective Studies
/ Signet-ring cell gastric carcinoma
/ Stomach Neoplasms - mortality
/ Stomach Neoplasms - surgery
/ Survival
/ Survival Analysis
/ Tumors
2021
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Optimal care and survival for signet-ring cell and non-signet-ring cell gastric cancer are more achievable at academic cancer centers
by
Farma, Jeffrey M.
, Deng, Mengying
, Handorf, Elizabeth
, Greco, Stephanie H.
, Moslim, Maitham A.
in
Academic
/ Academic Medical Centers - standards
/ Academic Medical Centers - statistics & numerical data
/ Adult
/ Aged
/ Aged, 80 and over
/ Cancer
/ Cancer therapies
/ Carcinoma, Signet Ring Cell - mortality
/ Carcinoma, Signet Ring Cell - surgery
/ Cell survival
/ Chemotherapy
/ Community centers
/ Comprehensive cancer center
/ Dissection
/ Female
/ Gastrectomy
/ Gastric cancer
/ Gastrointestinal surgery
/ Humans
/ Lymph nodes
/ Lymphatic system
/ Male
/ Middle Aged
/ Mortality
/ Patients
/ Population studies
/ Quality of Health Care
/ Retrospective Studies
/ Signet-ring cell gastric carcinoma
/ Stomach Neoplasms - mortality
/ Stomach Neoplasms - surgery
/ Survival
/ Survival Analysis
/ Tumors
2021
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Optimal care and survival for signet-ring cell and non-signet-ring cell gastric cancer are more achievable at academic cancer centers
by
Farma, Jeffrey M.
, Deng, Mengying
, Handorf, Elizabeth
, Greco, Stephanie H.
, Moslim, Maitham A.
in
Academic
/ Academic Medical Centers - standards
/ Academic Medical Centers - statistics & numerical data
/ Adult
/ Aged
/ Aged, 80 and over
/ Cancer
/ Cancer therapies
/ Carcinoma, Signet Ring Cell - mortality
/ Carcinoma, Signet Ring Cell - surgery
/ Cell survival
/ Chemotherapy
/ Community centers
/ Comprehensive cancer center
/ Dissection
/ Female
/ Gastrectomy
/ Gastric cancer
/ Gastrointestinal surgery
/ Humans
/ Lymph nodes
/ Lymphatic system
/ Male
/ Middle Aged
/ Mortality
/ Patients
/ Population studies
/ Quality of Health Care
/ Retrospective Studies
/ Signet-ring cell gastric carcinoma
/ Stomach Neoplasms - mortality
/ Stomach Neoplasms - surgery
/ Survival
/ Survival Analysis
/ Tumors
2021
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Optimal care and survival for signet-ring cell and non-signet-ring cell gastric cancer are more achievable at academic cancer centers
Journal Article
Optimal care and survival for signet-ring cell and non-signet-ring cell gastric cancer are more achievable at academic cancer centers
2021
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Overview
Western literature lacks large-scale population studies comparing the influence of academic and high-volume (HV) versus low-volume (LV) cancer centers on gastric cancer oncologic outcomes.
The National Cancer Database from 2004 to 2016 was used.
22871 patients were studied. Patients with stage III signet-ring cell gastric carcinoma (SRGC) received neoadjuvant treatment (NAT) more frequently at academic and HV comprehensive cancer centers (OR: 4.27 and 2.42; p < 0.0001 and 0.009) compared to community centers. Patients with stage III non-SRGC (NSRGC) had a 2.4 times higher odds of receiving NAT at academic centers. The R1 resection rate for NSRGC was lower at academic centers (OR: 0.67; p = 0.0018). Lymph node harvest ≥15 nodes was 1.6 and 1.9 times higher at academic centers for NSRGC and SRGC, respectively. Patients treated at academic centers had a significantly improved overall survival (OS).
Treatment at academic centers is associated with significant improvements in oncologic metrics and OS.
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•Academic outperform community centers in management of resectable gastric cancer.•Despite delay in treatment initiation, survival is improved at academic centers.•Survival is greater in signet-ring cell gastric cancer treated at academic centers.
Publisher
Elsevier Inc,Elsevier Limited
Subject
/ Academic Medical Centers - standards
/ Academic Medical Centers - statistics & numerical data
/ Adult
/ Aged
/ Cancer
/ Carcinoma, Signet Ring Cell - mortality
/ Carcinoma, Signet Ring Cell - surgery
/ Female
/ Humans
/ Male
/ Patients
/ Signet-ring cell gastric carcinoma
/ Stomach Neoplasms - mortality
/ Survival
/ Tumors
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