Asset Details
Do you wish to reserve the book?
Impact of Epidermal Growth Factor and Transforming Growth Factor Beta-1 on the Release of Fibrinolytic Factors from Cultured Endometrial and Ovarian Endometriotic Stromal Cells
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Impact of Epidermal Growth Factor and Transforming Growth Factor Beta-1 on the Release of Fibrinolytic Factors from Cultured Endometrial and Ovarian Endometriotic Stromal Cells
Do you wish to request the book?
Impact of Epidermal Growth Factor and Transforming Growth Factor Beta-1 on the Release of Fibrinolytic Factors from Cultured Endometrial and Ovarian Endometriotic Stromal Cells
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Impact of Epidermal Growth Factor and Transforming Growth Factor Beta-1 on the Release of Fibrinolytic Factors from Cultured Endometrial and Ovarian Endometriotic Stromal Cells
2003
Overview
We have investigated whether there are any differences in the release of urokinase plasminogen activator (uPA) and its inhibitor (PAI-1) from cultured endometrial and endometriotic stromal cells, and whether the release is regulated by epidermal growth factor (EGF) or transforming growth factor β1 (TGFβ1). The cells were isolated from endometriomas and endometrium from women with and without endometriosis. After treatment with EGF or TGF and in untreated controls, incubated media collected at 0, 24, 48 and 72 h were analyzed by ELISA. Stromal cells from all three types of tissues released uPA and PAI-1, but the soluble receptor of uPA was not measurable in any group. The basal release of uPA and PAI-1 from endometriotic cells was higher than from endometrial cells. The uPA release in endometriotic cells was reduced with and without the addition of EGF (p < 0.05) or TGFβ1 (p < 0.05). EGF increased the release of PAI-1 from stromal cells from women without endometriosis (p < 0.05) but decreased the release of PAI-1 from stromal cells from endometriotic women (p < 0.05). TGFβ1 increased the release of PAI-1 from endometriotic cells (p < 0.05) but had no effect in endometrial cells.
Publisher
Karger,S. Karger AG
Subject
/ Biological and medical sciences
/ Enzyme-Linked Immunosorbent Assay
/ Epidermal Growth Factor - pharmacology
/ Female
/ Gynecology. Andrology. Obstetrics
/ Humans
/ Plasminogen Activator Inhibitor 1 - metabolism
/ Plasminogen Activator Inhibitor 1 - secretion
/ Stromal Cells - drug effects
/ Transforming Growth Factor beta - pharmacology
