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Anti-Staphylococcal Humoral Immune Response in Persistent Nasal Carriers and Noncarriers of Staphylococcus aureus
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Anti-Staphylococcal Humoral Immune Response in Persistent Nasal Carriers and Noncarriers of Staphylococcus aureus
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Journal Article
Anti-Staphylococcal Humoral Immune Response in Persistent Nasal Carriers and Noncarriers of Staphylococcus aureus
2009
Overview
BackgroundPersistent carriers have a higher risk of Staphylococcus aureus infections than noncarriers but a lower risk of bacteremia-related death. Here, the role played by anti-staphylococcal antibodies was studied MethodsSerum samples from 15 persistent carriers and 19 noncarriers were analyzed for immunoglobulin (Ig) G, IgA, and IgM binding to 19 S. aureus antigens, by means of Luminex technology. Nasal secretions and serum samples obtained after 6 months were also analyzed ResultsMedian serum IgG levels were significantly higher in persistent carriers than in noncarriers for toxic shock syndrome toxin (TSST)–1 (median fluorescence intensity [MFI] value, 11,554 vs. 4291; P<.001) and staphylococcal enterotoxin (SE) A (742 vs. 218; P<.05); median IgA levels were higher for TSST-1 (P<.01), SEA, and clumping factor (Clf) A and B (P<.05). The in vitro neutralizing capacity of anti–TSST-1 antibodies was correlated with the MFI value (R2=0.93) and was higher in persistent carriers (90.6% vs. 70.6%; P<.05). Antibody levels were stable over time and correlated with levels in nasal secretions (for IgG, R2=0.87; for IgA, R2=0.77) ConclusionsAntibodies to TSST-1 have a neutralizing capacity, and median levels of antibodies to TSST-1, SEA, ClfA, and ClfB are higher in persistent carriers than in noncarriers. These antibodies might be associated with the differences in the risk and outcome of S. aureus infections between nasal carriers and noncarriers
Publisher
The University of Chicago Press,University of Chicago Press,Oxford University Press
Subject
/ Antibodies, Bacterial - biosynthesis
/ Antibodies, Bacterial - blood
/ Antigens
/ Antigens, Bacterial - immunology
/ Bacteria
/ Bacterial Toxins - immunology
/ Biological and medical sciences
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Immunoglobulin G - biosynthesis
/ Staphylococcal Infections - immunology
/ Staphylococcus aureus - immunology
/ Toxicity
