Asset Details
Do you wish to reserve the book?
Evaluation of a High-Dose Chemotherapy Protocol with No Maintenance Therapy for Dogs with Lymphoma
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Evaluation of a High-Dose Chemotherapy Protocol with No Maintenance Therapy for Dogs with Lymphoma
Do you wish to request the book?
Evaluation of a High-Dose Chemotherapy Protocol with No Maintenance Therapy for Dogs with Lymphoma
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Evaluation of a High-Dose Chemotherapy Protocol with No Maintenance Therapy for Dogs with Lymphoma
2000
Overview
Abstract
The purpose of this study was to evaluate the efficacy and toxicity of an intensified dose protocol with no maintenance phase for the treatment of canine lymphoma. Forty-nine dogs all weighing more than 15 kg were entered. Dogs were staged and treated with a modified version of the University of Wisconsin (UW)-Madison protocol for lymphoma. Modifications included increased dosages of cyclophosphamide (250 mg/m2 compared to 200 mg/m2) and doxorubicin (37.5 mg/m2 compared to 30 mg/m2), with no crossover to chlorambucil or methotrexate. After 25 weeks on protocol (17 treatments), therapy was discontinued and dogs were monitored for relapse on a monthly basis. Disease-free interval (DFI) and overall survival were compared to 55 historical controls treated with the UW-Madison protocol. The 2 groups were comparable with respect to age, sex, breed, stage, presence of hypercalcemia, and CD3 status; a trend toward more substage b dogs was present in the high-dose group (P= .076). When comparing response rate, DFI, death due to disease, and death due to treatment-related toxicity, more dogs were dead due to toxicity (P < .001; odds ratio = 8.8) in the high-dose group. Overall survival between the high-dose and control groups did not differ significantly (P= .55) at 270 and 318 days, respectively. The intensified dose protocol is an option for owners who are willing to risk higher toxicity for a shorter protocol with no statistical difference in survival from the UW-Madison protocol.
Publisher
Blackwell Publishing Ltd,Oxford University Press
Subject
/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use
/ Asparaginase - administration & dosage
/ Canine
/ Chlorambucil - administration & dosage
/ Cyclophosphamide - administration & dosage
/ Dogs
/ Dose-Response Relationship, Drug
/ Doxorubicin - administration & dosage
/ Female
/ Lymphoma
/ Male
/ Methotrexate - administration & dosage
/ Prednisone - administration & dosage
/ Toxicity
