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Long-term outcomes of below-the-knee bypass surgery using heparin-bonded expanded polytetrafluoroethylene grafts
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Long-term outcomes of below-the-knee bypass surgery using heparin-bonded expanded polytetrafluoroethylene grafts
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Journal Article
Long-term outcomes of below-the-knee bypass surgery using heparin-bonded expanded polytetrafluoroethylene grafts
2025
Overview
Purpose
To report the outcomes of below-the-knee (BK) bypass surgery using heparin-bonded expanded polytetrafluoroethylene (ePTFE) grafts, performed in two centers since its launch in Japan.
Methods
We conducted a retrospective analysis of databases from two medical centers, evaluating 51 limbs in 42 consecutive patients with peripheral arterial disease (PAD), who underwent BK bypass surgery using heparin-bonded ePTFE grafts between October, 2013 and April, 2023.
Results
Thirty-three limbs (64.7%) were classified as Rutherford category 4–6 and 33 limbs (64.7%) had a history of ipsilateral revascularization. Technical success was achieved in 98% of the patients. The 30 day mortality rate was 2.4% (
n
= 1) and the overall 30 day complication rate was 9.5% (
n
= 4). The median follow-up period was 38 (interquartile range 13–67) months. Three patients required major amputation and 14 died during follow-up. Primary patency rates at 1, 3, and 5 years were 67.8%, 57.5%, and 46.5%, respectively, while secondary patency rates for these periods were 84.6%, 70.0%, and 66.0%, respectively. Overall survival rates at 1, 3, and 5 years were 90.1%, 74.5%, and 70.9%, respectively.
Conclusions
BK bypass surgery using heparin-bonded ePTFE graft is a viable and durable option for patients with PAD, who are deemed unsuitable for autologous vein bypass surgery.
Publisher
Springer Nature Singapore,Springer Nature B.V
Subject
/ Blood Vessel Prosthesis Implantation - methods
/ Chronic obstructive pulmonary disease
/ Coated Materials, Biocompatible
/ Diabetes
/ Female
/ Heparin - administration & dosage
/ Humans
/ Male
/ Medicine
/ Patients
/ Peripheral Arterial Disease - mortality
/ Peripheral Arterial Disease - surgery
/ Surgeons
/ Surgery
