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Masked polycythemia vera in a patient 5 years after gastric bypass surgery: A diagnostic pitfall
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Masked polycythemia vera in a patient 5 years after gastric bypass surgery: A diagnostic pitfall
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Journal Article
Masked polycythemia vera in a patient 5 years after gastric bypass surgery: A diagnostic pitfall
2025
Overview
The three major criteria are 1) An elevated hemoglobin (≥16.5 g/dL in men and ≥16.0 g/dL in women) or elevated hematocrit (≥49% in men and ≥48% in women); 2) Bone marrow biopsy specimen with age-adjusted hypercellularity with panmyelosis and pleomorphic megakaryocytic proliferation, and 3) Presence of JAK2 p.V617F or JAK2 exon 12 mutation; the minor criterion is a subnormal EPO level [1, 2]. Low serum EPO level and appropriate bone marrow morphology with JAK2 mutation are useful clues for an accurate diagnosis and management in masked PV patients with iron deficiency due to gastric bypass surgery. CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.
