Asset Details
Do you wish to reserve the book?
Inducible degradation of lncRNA Sros1 promotes IFN-γ-mediated activation of innate immune responses by stabilizing Stat1 mRNA
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Inducible degradation of lncRNA Sros1 promotes IFN-γ-mediated activation of innate immune responses by stabilizing Stat1 mRNA
Do you wish to request the book?
Inducible degradation of lncRNA Sros1 promotes IFN-γ-mediated activation of innate immune responses by stabilizing Stat1 mRNA
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Inducible degradation of lncRNA Sros1 promotes IFN-γ-mediated activation of innate immune responses by stabilizing Stat1 mRNA
2019
Overview
Interferon-γ (IFN-γ) is essential for the innate immune response to intracellular bacteria. Noncoding RNAs and RNA-binding proteins (RBPs) need to be further considered in studies of regulation of the IFN-γ-activated signaling pathway in macrophages. In the present study, we found that the microRNA miR-1 promoted IFN-γ-mediated clearance of
Listeria monocytogenes
in macrophages by indirectly stabilizing the
Stat1
messenger RNA through the degradation of the cytoplasmic long noncoding RNA Sros1. Inducible degradation or genetic loss of Sros1 led to enhanced IFN-γ-dependent activation of the innate immune response. Mechanistically, Sros1 blocked the binding of
Stat1
mRNA to the RBP CAPRIN1, which stabilized the
Stat1
mRNA and, consequently, promoted IFN-γ–STAT1-mediated innate immunity. These observations shed light on the complex RNA–RNA regulatory networks involved in cytokine-initiated innate responses in host–pathogen interactions.
Cao and colleagues found that the microRNA miR-1 promotes IFN-γ-mediated clearance of
Listeria monocytogenes
in macrophages by stabilizing the
Stat1
mRNA through the degradation of the cytoplasmic long noncoding RNA Sros1.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 692/420
/ Animals
/ Biomedical and Life Sciences
/ Cell Cycle Proteins - metabolism
/ Interferon-gamma - metabolism
/ Listeria
/ Listeria monocytogenes - physiology
/ Mice
/ miRNA
/ mRNA
/ RNA, Long Noncoding - genetics
/ RNA, Long Noncoding - metabolism
/ STAT1 Transcription Factor - genetics
