Journal Article

Special issues related to the diagnosis and management of acquired aplastic anemia in countries with restricted resources, a report on behalf of the Eastern Mediterranean blood and marrow transplantation (EMBMT) group and severe aplastic anemia working party of the European Society for blood and marrow transplantation (SAAWP of EBMT)

Dufour, Carlo, Osman Ahmed Syed, Chaudhry Qamar-Un-Nisa, Bazarbachi Ali, Alzahrani Hazzaa, de Latour Regis, Ljungman Per, Chaudhri Naeem, Austin, Kulasekararaj, Al-Khabori Murtadha, Marsh, Judith, Risitano Antonio, Halkes Constantijn, Parvez, Ahmad, Alotaibi Sultan, Rihani Rawad, Raheel, Iftikhar, Hamidieh, Amir Ali, Alahmari Ali, De La Fuente Josu, El Fakih Riad, Rasheed Walid, Passweg Jakob, Höchsmann Britta, Cesaro Simone, Aljurf Mahmoud, Gergis Usama, Bacigalupo, Andrea, Ben Othman Tarek, Mohamed-Amine, Bekadja, Elhaddad Alaa, Albeirouti Bassim, Salem, Alshemmari

2021

Overview

Aplastic anemia is a relatively rare but potentially fatal disorder, with a reported higher incidence in developing countries in comparison to the West. There are significant variations in epidemiological as well as etiological factors of bone marrow failure syndromes in the developing countries in comparison to the developed world. Furthermore, the management of bone marrow failure syndromes in resource constraint settings has significant challenges including delayed diagnosis and referral, limited accessibility to healthcare facilities, treatment modalities as well as limitations related to patients who require allogeneic stem cell transplantation. Here we will provide a review of the available evidence related to specific issues of aplastic anemia in the developing countries and we summarize suggested recommendations from the Eastern Mediterranean blood and bone marrow transplantation (EMBMT) group and the severe aplastic anemia working party of the European Society of blood and marrow transplantation (SAAWP of EBMT) related to the diagnosis and therapeutic options in countries with restricted resources.

• Publisher: Nature Publishing Group
• Subject: Anemia / Aplastic anemia / Blood / Bone marrow / Bone marrow transplantation / Developing countries / Diagnosis / Disorders / Epidemiology / Etiology / Health care facilities / LDCs / Stem cell transplantation / Stem cells / Transplantation