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Characterization of Immunoglobulin Heavy Locus Rearrangements in Molecular Subtypes of Childhood B‐Cell Precursor Acute Lymphoblastic Leukemia
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Characterization of Immunoglobulin Heavy Locus Rearrangements in Molecular Subtypes of Childhood B‐Cell Precursor Acute Lymphoblastic Leukemia
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Journal Article
Characterization of Immunoglobulin Heavy Locus Rearrangements in Molecular Subtypes of Childhood B‐Cell Precursor Acute Lymphoblastic Leukemia
2025
Overview
Biased IGH VDJ recombination has been previously described in childhood B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL), although its causes are not yet fully understood. This study assesses differential features in 565 IGH clonotypes from BCP‐ALL molecular subsets against 560 clonotypes from bone marrow donors. Leukemia clonotypes were enriched for IGHV6‐1 segments in the KMT2A rearranged and B‐other subtypes, while IGHV3‐23 was enriched in TCF3::PBX1. ETV6::RUNX1 presented a topological gap in the usage of central IGHV segments. BCP‐ALL also presented shorter CDR3 regions, higher GC content, and lower productivity. Interestingly, productive clonotypes tended to be absent after induction therapy.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
Subject
