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Atovaquone/Proguanil Therapy for Plasmodium falciparum and Plasmodium vivax Malaria in Indonesians Who Lack Clinical Immunity

by Barcus, Mazie J. , Miller, Gerri B. , Ling, Judith , Baird, J. Kevin , Basri, Hasan , Hoffman, Stephen L. , Bangs, Michael J. , Sismadi, Priyanto , Chulay, Jeffrey D. , Gramzinski, Robert , Lacy, Mark D. , Maguire, Jason D. , Fryauff, David J.

in Adolescent / Adult / Aged / Animals / Antimalarials - therapeutic use / Atovaquone / Double-Blind Method / Drug Resistance / Drug Therapy, Combination / Female / Humans / Indonesia - epidemiology / Malaria, Falciparum - drug therapy / Malaria, Falciparum - immunology / Malaria, Vivax - drug therapy / Malaria, Vivax - immunology / Male / Middle Aged / Naphthoquinones - therapeutic use / Plasmodium falciparum - drug effects / Plasmodium vivax - drug effects / Proguanil - therapeutic use / Treatment Outcome

2002

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Atovaquone/Proguanil Therapy for Plasmodium falciparum and Plasmodium vivax Malaria in Indonesians Who Lack Clinical Immunity

2002

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Atovaquone/Proguanil Therapy for Plasmodium falciparum and Plasmodium vivax Malaria in Indonesians Who Lack Clinical Immunity

2002

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Journal Article

Atovaquone/Proguanil Therapy for Plasmodium falciparum and Plasmodium vivax Malaria in Indonesians Who Lack Clinical Immunity

Barcus, Mazie J.,

Miller, Gerri B.,

Ling, Judith,

Baird, J. Kevin,

Basri, Hasan,

Hoffman, Stephen L.,

Bangs, Michael J.,

Sismadi, Priyanto,

Chulay, Jeffrey D.,

Gramzinski, Robert,

Lacy, Mark D.,

Maguire, Jason D.,

Fryauff, David J.

2002

Overview

Thirty-eight of 295 subjects participating in a randomized, double-blind, placebo-controlled trial of the efficacy of daily administration of atovaquone/proguanil for malaria prevention developed malaria at some time during the 20-week prophylaxis period. These subjects (3 atovaquone/proguanil recipients and 35 placebo recipients) were treated with 4 tablets of atovaquone/proguanil per day for 3 days. Atovaquone/proguanil provided safe, well-tolerated, and effective therapy for uncomplicated malaria in nonimmune Indonesians.

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Publisher

The University of Chicago Press

Subject

Adolescent

/ Adult

/ Aged

/ Animals

/ Antimalarials - therapeutic use

/ Atovaquone

/ Double-Blind Method