Journal Article

Early Clinical Experience with Dapagliflozin in Children with Heart Failure

Kemna, Mariska S., Newland, David M., Friedland-Little, Joshua M., Albers, Erin L., Hong, Borah J., Law, Yuk M., Ahmed, Humera

2023

Overview

Pediatric heart failure (HF) is associated with significant morbidity and mortality. Medical treatment for pediatric HF is largely derived from adult studies. Previously, there has been no described use of dapagliflozin in pediatric HF patients. We describe our single-center experience using dapagliflozin in addition to standard HF medical therapy in 38 pediatric HF patients since January 2020. Median age was 12.2 years (interquartile range 6.2–17.5). Majority of patients had dilated cardiomyopathy (68.4%) and reduced left ventricular ejection fraction (LVEF) of 40% or less (65.8%). HF regimens commonly included sacubitril/valsartan, beta-blocker, mineralocorticoid receptor antagonist, and loop diuretic. Median follow-up from dapagliflozin initiation for the whole cohort was 130 days (IQR 76–332). Median B-type natriuretic peptide decreased significantly from 222 to 166 pg/mL at latest clinical follow-up ( P  = .04). Estimated glomerular filtration rate trended lower at latest follow-up but was not significant from baseline. There were no clinically significant changes in blood chemistries or vital signs after initiation of dapagliflozin. No patients experienced symptomatic hypoglycemia or hypovolemia. Six patients (15.8%) experienced a symptomatic urinary tract infection necessitating antibiotic treatment. In a separate analysis of 16 patients with dilated cardiomyopathy who received dapagliflozin for a median of 313 days (IQR 191–414), median LVEF increased significantly from 32 to 37.2% ( P  = .006). Dapagliflozin, when added to a background of guideline-directed medical therapy, appears well tolerated in children with HF. Larger studies are needed to evaluate safety and efficacy of dapagliflozin in this population.

• Publisher: Springer US,Springer,Springer Nature B.V
• Subject: Adult / Beta blockers / Blood pressure / Cardiac Surgery / Cardiology / Cardiomyopathy / Cardiomyopathy, Dilated / Care and treatment / Chi-square test / Child / Creatinine / Dapagliflozin / Diuretics / Ejection fraction / Glucose / Health aspects / Heart Failure / Heart rate / Heart transplants / Hemoglobin / Hospitalization / Humans / Medicine / Medicine & Public Health / Mortality / Original Article / Patients / Pediatrics / Stroke Volume / Treatment Outcome / Urinary tract infections / Vascular Surgery / Ventricular Function, Left