Journal Article

Interleukin 27 is up-regulated in patients with active inflammatory bowel disease

Fonseca Camarillo, Gabriela, Yamamoto-Furusho, Jesús K., Furuzawa Carballeda, Janette

2016

Overview

The aim of the study was to characterize and quantify tissue gene and protein expression of IL-27 in ulcerative colitis (UC) and Crohn’s disease (CD) patients. This is an observational and cross-sectional study. Fifty-four patients with IBD were studied: 27 active UC, 12 inactive UC, 10 active CD, and 5 inactive CD. All patients belonged to the Inflammatory Bowel Disease Clinic at the Instituto Nacional de Ciencias Médicas y Nutrición. We found that IL-27 gene expression was significantly higher in active UC versus inactive UC group ( P  = 0.015). The IL-27 mRNA expression was increased in patients with active CD compared with inactive CD disease ( P  = 0.035). The percentage of IL-27 immunoreactive cells was higher in active UC versus active CD patients and non-inflamed tissue controls. The IL-27 was significantly elevated in active UC and CD patients, and it was associated with disease severity.

• Publisher: Springer US,Springer Nature B.V
• Subject: Adult / Allergology / Biomedical and Life Sciences / Biomedicine / Colitis, Ulcerative - immunology / Colon - metabolism / Colon - pathology / Crohn Disease - immunology / Cross-Sectional Studies / Cytokines / Disease Progression / Female / Humans / Immune system / Immunology / Inflammation / Inflammatory bowel disease / Interleukin-27 - genetics / Interleukin-27 - metabolism / Internal Medicine / Intestinal Mucosa - metabolism / Intestinal Mucosa - pathology / Male / Medicine/Public Health / Middle Aged / Original Article / Protein expression / RNA, Messenger - analysis / Up-Regulation