Asset Details
Do you wish to reserve the book?
Negative Selection of Semimature CD4+8- HSA+ Thymocytes Requires the BH3-Only Protein Bim but Is Independent of Death Receptor Signaling
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Negative Selection of Semimature CD4+8- HSA+ Thymocytes Requires the BH3-Only Protein Bim but Is Independent of Death Receptor Signaling
Do you wish to request the book?
Negative Selection of Semimature CD4+8- HSA+ Thymocytes Requires the BH3-Only Protein Bim but Is Independent of Death Receptor Signaling
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Negative Selection of Semimature CD4+8- HSA+ Thymocytes Requires the BH3-Only Protein Bim but Is Independent of Death Receptor Signaling
2004
Overview
T cell receptor/CD3 ligation induces apoptosis in semimature CD4+8- HSA+ thymocytes, and this helps establish immunological tolerance and constitutes one of the safeguards against autoimmune disease. We analyzed several knockout and transgenic mouse lines and found that T cell receptor/CD3-ligation-induced killing of semimature thymocytes occurred independently of Fas and \"death receptor\" signaling in general but required the proapoptotic BH3-only protein Bim and could be inhibited by Bcl-2. Loss of Apaf-1 or caspase-9, which act downstream of the Bcl-2 family protein family, provided only minor protection, indicating that the \"apoptosome\" functions as an amplifier rather than as an essential initiator of this death program. These results reveal the mechanisms of apoptosis in negative selection of semimature thymocytes and have implications for immunological tolerance and autoimmunity.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Apoptosis Regulatory Proteins
/ Apoptotic Protease-Activating Factor 1
/ Carrier Proteins - metabolism
/ Clonal Deletion - immunology
/ Genetics
/ Killing
/ Membrane Proteins - metabolism
/ Mice
/ Proto-Oncogene Proteins - metabolism
/ Proto-Oncogene Proteins c-bcl-2 - metabolism
/ Receptors, Antigen, T-Cell - metabolism
