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Selection of Lactobacillus fermentum strains able to durably colonize the digestive tract of mice harbouring a complex human flora
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Selection of Lactobacillus fermentum strains able to durably colonize the digestive tract of mice harbouring a complex human flora
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Journal Article
Selection of Lactobacillus fermentum strains able to durably colonize the digestive tract of mice harbouring a complex human flora
1999
Overview
Sixteen Lactobacillus fermentum strains were isolated from the fecal microflora of pigs. They were challenged in vivo, in gnotobiotic mice harboring a porcine flora devoid of lactobacilli. Some of the strains were able to colonize the digestive tract of the mice at high population levels, whilst other strains were eliminated. Chromosomal DNA restriction analysis performed on both colonizing (C-type) and non-colonizing (NC-type) strains were analyzed by pulsed-field gel electrophoresis. Strains LEMPL9 (C-type) and LEM 1.16A (NC-type) exhibited a high degree or homology. When challenged in mice harboring a simplified anaerobic flora, LEMPL9 was able to colonize the digestive tract of the animals whereas LEM1.16A was again eliminated. Mutagenesis performed on LEM1.16A allowed the isolation of a mutant able to colonize the gut of mice harboring the simplified anaerobic flora or a complex human flora, suggesting that genes involved in colonization process might have been affected to enhance the bacterium's colonization ability.
Publisher
Blackwell Publishing Ltd,Blackwell,Oxford University Press,Wiley-Blackwell
Subject
Animal, plant and microbial ecology
/ bacteria
/ Biological and medical sciences
/ DNA
/ Ecology
/ flora
/ Fundamental and applied biological sciences. Psychology
/ genes
/ Homology
/ humans
/ mice
/ Microbiology and Parasitology
/ Mutants
/ Normal microflora of man and animals. Rumen
/ Pulsed-field gel electrophoresis
/ Swine
