Journal Article

Treating hypertension with a device that slows and regularises breathing: a randomised, double-blind controlled study

Gavish, B, Zlotnikov, E, Ben-Zvi, N, Schein, MH, Melmed, RN, Naveh, P, Herz, M, Knishkowy, B, Rosner-Kahana, D

2001

Overview

To examine the efficacy of a new device, which slows and regularises breathing, as a non-pharmacological treatment of hypertension and thus to evaluate the contribution of breathing modulation in the blood pressure (BP) reduction. Randomised, double-blind controlled study, carried out in three urban family practice clinics in Israel. Sixty-five male and female hypertensives, either receiving antihypertensive drug therapy or unmedicated. Four patients dropped out at the beginning of the study. Self treatment at home, 10 minutes daily for 8 consecutive weeks, using either the device (n = 32), which guides the user towards slow and regular breathing using musical sound patterns, or a Walkman, with which patients listened to quiet music (n = 29). Medication was unchanged 2 months prior to and during the study period. Systolic BP, diastolic BP and mean arterial pressure (MAP) changes from baseline. BP reduction in the device group was significantly greater than a predetermined 'clinically meaningful threshold' of 10.0, 5.0 and 6.7 mm Hg for the systolic BP, diastolic BP and MAP respectively (P = 0.035, P = 0.0002 and P = 0.001). Treatment with the device reduced systolic BP, diastolic BP and MAP by 15.2, 10.0 and 11.7 mm Hg respectively, as compared to 11.3, 5.6 and 7.5 mm Hg (P = 0.14, P = 0.008, P = 0.03) with the Walkman. Six months after treatment had stopped, diastolic BP reduction in the device group remained greater than the 'threshold' (P < 0.02) and also greater than in the walkman group (P = 0.001). The device was found to be efficacious in reducing high BP during 2 months of self-treatment by patients at home. Breathing pattern modification appears to be an important component in this reduction.

• Publisher: Nature Publishing,Nature Publishing Group
• Subject: Adult / Aged / Antihypertensives / Arterial hypertension. Arterial hypotension / Biological and medical sciences / Blood and lymphatic vessels / Blood pressure / Blood Pressure - physiology / Blood Pressure Determination / Breathing Exercises / Cardiology. Vascular system / Clinical manifestations. Epidemiology. Investigative techniques. Etiology / Double-Blind Method / Double-blind studies / Drug therapy / Female / Heart Rate - physiology / Humans / Hypertension / Hypertension - physiopathology / Hypertension - therapy / Male / Medical sciences / Middle Aged / Music Therapy - instrumentation / Music Therapy - methods / Patients