Journal Article

The efficacy of light-guiding microneedle patch for stimulating hair growth in androgenetic alopecia

Sirithanabadeekul, Punyaphat, Adulyaritthikul, Punyanuch, Thongma, Sattra, Tantisantisom, Kittipong, Charoensuksira, Sasin, Rayanasukha, Yossawat, Rattanapirat, Suthasinee, Meephansan, Jitlada

2024

Overview

Androgenetic alopecia (AGA) is the most common form of hair loss characterized by miniaturization of hair follicles. Low-level light therapy (LLLT) and microneedling have shown potential in promoting hair regrowth. This study aims to evaluate the efficacy of an innovative light-emitting diode (LED) helmet cooperated with a novel light-guiding microneedle patch (LMNP) for stimulating hair growth in AGA. In this randomized clinical trial, 16 AGA patients received treatments using light-guiding microneedle patches (LMNPs) illuminated by a LED helmet equipped with green (522 nm) and red (633 nm) LEDs, delivering 50 mW/cm2 power and 40 J/cm2 energy. Treatments were applied weekly for 24 weeks, targeting the frontal recession area. The right side of the scalp was treated with green light and the left with red light, each combined with a LMNP featuring 900 µm height needles at a density of 105 per square centimeter. Hair density and diameter, along with patient and physician satisfaction scores, were assessed monthly. Both red and green LED treatments with LMNP, significantly enhanced hair density and diameter. Satisfaction scores, as reported by both physicians and participants, increased over time. Comparative analyses revealed no statistically significant differences in average satisfaction scores or in changes in hair density and diameter between the groups by the end of the study. Additionally, no serious adverse effects were reported, highlighting the safety of the treatments. The combined Light sources which is portable LED helmet and LMNPs shows promise as a non-invasive, effective treatment for AGA, with similar efficacy between red and green wavelengths.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Adult / Alopecia / Alopecia - radiotherapy / Alopecia - therapy / Baldness / Comparative analysis / Dermatology / Female / Follicles / Hair / Hair - growth & development / Hair - radiation effects / Hair Follicle - growth & development / Hair Follicle - radiation effects / Helmets / Humans / Light emitting diodes / Light therapy / Low-Level Light Therapy - instrumentation / Low-Level Light Therapy - methods / Male / Medicine / Medicine & Public Health / Middle Aged / Needles / Original Paper / Patient Satisfaction / Patients / Propagation / Scalp / Statistical analysis / Treatment Outcome