Journal Article

Detecting endolymphatic hydrops in patients with cranial nerve VIII schwannoma using hydrops MR examination

Meng, Ling-Chen, Young, Yi-Ho, Wang, Yu-Fen

2025

Overview

Purpose This study utilized Hydrops MRI in patients with cranial nerve (CN) VIII schwannoma to assess the concomitance with endolymphatic hydrops (EH), aiming to elucidate the mechanism of hydrops formation in these patients. Methods Twenty-six patients diagnosed as CN VIII schwannoma including vestibular schwannoma (VS) in 24 and intracochlear schwannoma (ICS) in 2 were enrolled. Fifteen patients received radiosurgery and 11 patients opted for a wait-and-scan approach. All patients underwent an inner ear test battery, followed by Hydrops MRI. Based on Hydrops MRI, 6 patients (23%) with positive EH were assigned to Group A, while the other 20 patients showing negative EH were assigned to Group B. Results The abnormality rates of inner ear test battery in Group A ran from the audiometry (100%), cervical vestibular-evoked myogenic potential (cVEMP) test (83%), ocular VEMP (oVEMP) test (67%) to the caloric test (33%), exhibiting a significantly declining sequence. This declining sequence is consistent with the decreasing order in the prevalence of EH from the cochlea (83%), saccule (50%) to utricle (50%). However, Group B did not show such decreasing trend, indicating that Groups A and B did not share the common mechanism. The mean tumor size prior to radiosurgery was 1.91 ± 0.89 cm, which significantly reduced to 1.53 ± 0.60 cm at a mean interval of 6 years following radiosurgery. In contrast, tumor size remained unchanged in those opted for a wait-and-scan approach. Conclusion It is recommended to utilize Hydrops MRI for patients with CN VIII schwannoma during annual follow-up, particularly those experienced episodic vertigo and/or deteriorated hearing. The Hydrops MRI can not only monitor tumor size, but also detect the presence of EH, so as to guide treatment decision.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Adult / Aged / Audiometry / Endolymphatic Hydrops - diagnosis / Endolymphatic Hydrops - diagnostic imaging / Endolymphatic Hydrops - etiology / Female / Head and Neck Surgery / Humans / Magnetic Resonance Imaging - methods / Male / Medicine / Medicine & Public Health / Middle Aged / Neuroma, Acoustic - complications / Neuroma, Acoustic - diagnostic imaging / Neuroma, Acoustic - surgery / Neurosurgery / Otology / Otorhinolaryngology / Radiosurgery / Vestibular Evoked Myogenic Potentials / Young Adult