Asset Details
Do you wish to reserve the book?
Diesel Particulate Matter (DPM)-Induced Metabolic Disruption in Mice Is Mitigated by Sodium Copper Chlorophyllin (SCC)
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Diesel Particulate Matter (DPM)-Induced Metabolic Disruption in Mice Is Mitigated by Sodium Copper Chlorophyllin (SCC)
Do you wish to request the book?
Diesel Particulate Matter (DPM)-Induced Metabolic Disruption in Mice Is Mitigated by Sodium Copper Chlorophyllin (SCC)
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Diesel Particulate Matter (DPM)-Induced Metabolic Disruption in Mice Is Mitigated by Sodium Copper Chlorophyllin (SCC)
2025
Overview
Background/Objectives: The increasing prevalence of metabolic disorders underscores the need for effective interventions to mitigate environmental stressors such as diesel particulate matter (DPM), a major urban air pollutant. DPM is composed of fine carbonaceous particles that can induce systemic inflammation. This phenomenon results in metabolic dysfunction such as adipocyte hypertrophy, insulin resistance, and mitochondrial impairment in body tissues. Methods: This study investigated the impact of DPM exposure on murine lung, skeletal muscle, and adipose tissues and evaluated the protective effects of supplementation with sodium copper chlorophyllin (SCC). Results: Compared to controls, DPM-exposed mice exhibited significantly elevated oxidative stress markers (* p ≤ 0.05), systemic pro-inflammatory cytokines including TNF-α, MCP-1, IL-6, and IL-1β (* p ≤ 0.05), and adipocyte hypertrophy of both subcutaneous and visceral fat depots, supporting prior findings of DPM-induced metabolic dysfunction. SCC supplementation restored pulmonary ATP levels (* p ≤ 0.05), significantly reduced ROS production in lung and muscle tissue (* p ≤ 0.05), and significantly attenuated DPM-induced inflammatory cytokine secretion (* p ≤ 0.05), while lessening DPM-induced adipocyte hypertrophy. Conclusions: These effects highlight the antioxidant and anti-inflammatory potential of SCC, which likely mitigates systemic metabolic compromise by modulating mitochondrial function and inflammatory pathways. This study further demonstrated that SCC supplementation may be an effective intervention for alleviating the adverse effects of DPM exposure on metabolic and inflammatory compromise. Additional research may clarify a role for SCC in reducing systemic health risks associated with air pollution and offer a foundation for future translational research in human populations exposed to environmental pollutants.
Publisher
MDPI AG,MDPI
Subject
/ Adipose Tissue - drug effects
/ Animals
/ Body fat
/ Chlorophyllides - pharmacology
/ Chronic obstructive pulmonary disease
/ Copper
/ Inflammation - chemically induced
/ Lungs
/ Male
/ Mice
/ Muscle, Skeletal - drug effects
/ Muscle, Skeletal - metabolism
/ Oxidative Stress - drug effects
/ Particulate Matter - adverse effects
/ Particulate Matter - toxicity
/ Reactive Oxygen Species - metabolism
/ Sodium
