Journal Article

α-Ionone Protects Against UVB-Induced Photoaging in Human Dermal Fibroblasts

Park, Taesun, Park, Jinju, Tong, Tao, Kang, Wesuk, Moon, Youna

2019

Overview

Ultraviolet (UV) light-induced wrinkle formation is a major dermatological problem and is associated with alteration in collagen. Here, we investigated the potential of α-ionone, a naturally occurring aromatic compound, in regulation of UVB-induced photoaging in human Hs68 dermal fibroblasts and identified the mechanisms involved. We found that in human dermal fibroblasts, α-ionone inhibited UVB-induced loss of collagen. α-Ionone upregulated the molecules participating in the TGF-β–SMAD pathway (TGF-β1, phospho-SMAD2/3, Col1A1, and Col1A2), but downregulated the molecules involved in the MAPK–AP-1 signaling pathway (phospho-p38, phospho-JNK, phospho-ERK, phospho-c-Fos, phospho-c-Jun, MMP1, MMP3, and MMP9), in human dermal fibroblasts. α-Ionone treatment also increased hyaluronic acid contents, and this effect was accompanied by an upregulation of mRNA expression of genes (HAS1 and HAS2) involved in hyaluronic acid synthesis. Thus, α-ionone is effective in the prevention of UVB-induced decrease of collagen and hyaluronic acid in human dermal fibroblasts. We propose that α-ionone may prove beneficial for the prevention of UV-induced wrinkle formation and skin damage.

• Publisher: MDPI AG,MDPI
• Subject: Biosynthesis / Collagen / Collagen - metabolism / dermal fibroblasts / Dermis - pathology / Fibroblasts / Fibroblasts - drug effects / Fibroblasts - metabolism / Fibroblasts - radiation effects / Gene expression / Humans / hyaluronic acid / Hyaluronic Acid - metabolism / Kinases / Models, Biological / Norisoprenoids - chemistry / Norisoprenoids - pharmacology / photoaging / Physiology / Proteins / Skin Aging - drug effects / Skin Aging - radiation effects / Ultraviolet Rays / Up-Regulation - drug effects / α-ionone