Journal Article

Nanoparticles for active combination radio mitigating agents of zinc coumarate and zinc caffeinate in a rat model

Mansour, Nahla A., Guida, Mona S., AbuNour, Seham M., Ali, Eiman N., Elmasry, Samir A., Askar, Mostafa A., Abdel-Magied, Nadia, Ragab, Essam A.

2022

Overview

Zinc coumarate and zinc caffeinate nanoparticles (ZnCoNPs, ZnCaNPs) affect different biological processes. This study aimed to evaluate the mitigating action of ZnCoNPs in combination with ZnCaNPs against liver damage induced by gamma rays (γ-rays). Rats were exposed to 7 Gy of γ-rays and then injected intraperitoneally (i.p) with ZnCoNPs [2U/rat/day (5 mg/kg)] and ZnCaNPs [2U/rat/day (15 mg/kg)] for 7 consecutive days. The results showed that irradiated rats treated with ZnCoNPs (5 mg/kg/body weight) in combination with ZnCaNPs (15 mg/kg/body weight) for 7 days had a significant increases in body weight, antioxidant levels, T helper cell 4 (cluster of differentiation 4 (CD4)), and T cytotoxic cell 8 (cluster of differentiation 8 (CD8)), associated with a marked decrease in lipid peroxidation (LP), nitric oxide(NOx), total free radicals concentrate (TFRC ) , and DNA fragmentation. There were positive alterations in the morphological state, hematological parameters and the cell cycle phases. Additionally, the histopathological study demonstrated an improvement in the liver tissue of irradiated rats after treatment. Thus, ZnCoNPs and ZnCaNPs could be used as natural mitigating agents to reduce the hazards of ionizing radiation.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: animal models / Animals / Antioxidants / Antioxidants - pharmacology / Aquatic Pollution / Atmospheric Protection/Air Quality Control/Air Pollution / Biological activity / Body Weight / CD4 antigen / CD4-positive T-lymphocytes / CD8 antigen / Cell cycle / Cell differentiation / Clusters / Cytotoxicity / DNA fragmentation / Earth and Environmental Science / Ecotoxicology / Environment / Environmental Chemistry / Environmental Health / Environmental science / Free radicals / Gamma Rays / Hazard mitigation / Helper cells / histopathology / Ionizing radiation / irradiation / Lipid Peroxidation / Lipids / Liver / Lymphocytes T / Nanoparticles / Nitric oxide / Oxidative Stress / Peroxidation / pollution / Radiation hazards / Radiation-Protective Agents - pharmacology / radio / Rats / Research Article / Waste Water Technology / Water Management / Water Pollution Control / Zinc