Journal Article

The impact of subthalamic deep-brain stimulation in restoring motor symmetry in Parkinson’s disease patients: a prospective study

Corvol, Jean Christophe, Wirth, Thomas, Bereau, Matthieu, Barbosa, Raquel Pinheiro, Drapier, Sophie, Marques, Ana, Eusebio, Alexandre, Thobois, Stephane, Devos, David, Jarraya, Bechir, Hainque, Elodie, Brefel-Courbon, Christine, Ory-Magne, Fabienne, Bastos, Paulo, Maltete, David, Tranchant, Christine, Tir, Melissa, Rolland, Anne Sophie, Hopes, Lucie, Fabbri, Margherita, Moreau, Caroline, Rouaud, Tiphaine, Benatru, Isabelle, Giordana, Caroline, Rascol, Olivier, de Barros, Amaury, Guehl, Dominique, Hubsch, Cecile

2024

Overview

Background and objectives The impact of subthalamic deep-brain stimulation (STN-DBS) on motor asymmetry and its influence on both motor and non-motor outcomes remain unclear. The present study aims at assessing the role of STN-DBS on motor asymmetry and how its modulation translates into benefits in motor function, activities of daily living (ADLs) and quality of life (QoL). Methods Postoperative motor asymmetry has been assessed on the multicentric, prospective Predictive Factors and Subthalamic Stimulation in Parkinson’s Disease cohort. Asymmetry was evaluated at both baseline (pre-DBS) and 1 year after STN-DBS. A patient was considered asymmetric when the right-to-left MDS-UPDRS part III difference was ≥ 5. In parallel, analyses have been carried out using the absolute right-to-left difference. The proportion of asymmetric patients at baseline was compared to that in the post-surgery evaluation across different medication/stimulation conditions. Results 537 PD patients have been included. The proportion of asymmetric patients was significantly reduced after both STN-DBS and medication administration (asymmetric patients: 50% in pre-DBS MedOFF, 35% in MedOFF/StimON, 26% in MedON/StimOFF, and 12% in MedON/StimON state). Older patients at surgery and with higher baseline UPDRS II scores were significantly less likely to benefit from STN-DBS at the level of motor asymmetry. No significant correlation between motor asymmetry and ADLs (UPDRS II) or overall QoL (PDQ-39) score was observed. Asymmetric patients had significantly higher mobility, communication, and daily living PDQ-39 sub-scores. Conclusions Both STN-DBS and levodopa lead to a reduction in motor asymmetry. Motor symmetry is associated with improvements in certain QoL sub-scores.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V,Springer Verlag
• Subject: Activities of daily living / Asymmetry / Levodopa / Life Sciences / Medicine / Medicine & Public Health / Movement disorders / Neurodegenerative diseases / Neurology / Neurons and Cognition / Neuroradiology / Neurosciences / Original Communication / Parkinson's disease / Quality of life / Solitary tract nucleus / Surgery / Symmetry