Asset Details
Do you wish to reserve the book?
Clustering superparamagnetic iron oxide nanoparticles produces organ-targeted high-contrast magnetic resonance images
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Clustering superparamagnetic iron oxide nanoparticles produces organ-targeted high-contrast magnetic resonance images
Do you wish to request the book?
Clustering superparamagnetic iron oxide nanoparticles produces organ-targeted high-contrast magnetic resonance images
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Clustering superparamagnetic iron oxide nanoparticles produces organ-targeted high-contrast magnetic resonance images
2019
Overview
Superparamagnetic iron oxide nanoparticles (SPIONs) have been used as magnetic resonance imaging (MRI) contrast agents; however, a number of T2-weighted imaging SPIONs have been withdrawn due to their poor clinical contrast performance. Our aim was to significantly improve SPION T2-weighted MRI contrast by clustering SPIONs within novel chitosan amphiphiles.
Clustering SPIONs was achieved by encapsulation of hydrophobic-coated SPIONs with an amphiphilic chitosan polymer (GCPQ).
Clustering increases the spin-spin (
) to spin-lattice (
) relaxation ratio (
) from 3.0 to 79.1, resulting in superior contrast. Intravenously administered clustered SPIONs accumulated only in the liver and spleen; with the reduction in T2 relaxation confined, in the liver, to the extravascular space, giving clear MRI images of the liver vasculature.
Publisher
Future Medicine Ltd
