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Pharmacogenetic relevance of endothelial nitric oxide synthase polymorphisms and gene interactions
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Pharmacogenetic relevance of endothelial nitric oxide synthase polymorphisms and gene interactions
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Journal Article
Pharmacogenetic relevance of endothelial nitric oxide synthase polymorphisms and gene interactions
2018
Overview
Endothelial nitric oxide synthase (NOS3) is a key enzyme responsible for nitric oxide (NO) generation in the vascular endothelium. Endothelial dysfunction is characterized by reduced NO production, and is a hallmark of cardiovascular diseases. Drugs with cardiovascular action may activate NOS3 and result in NO release and vasodilation. Moreover, genetic variations affect NOS3 expression and activity, and may partially explain the variability in the responses to cardiovascular drugs. We reviewed NO signaling and genetic effects on NO formation, and the effects of
polymorphisms, haplotypes and gene-gene interactions within NO signaling pathways on the responses to cardiovascular drugs. We discuss the role of rare
variants and further gene-gene interactions analysis for the development of novel therapies for cardiovascular diseases.
Publisher
Future Medicine Ltd
Subject
/ Cardiovascular Agents - therapeutic use
/ Cardiovascular Diseases - drug therapy
/ Cardiovascular Diseases - genetics
/ DNA
/ Drugs
/ endothelial nitric oxide synthase
/ Enzymes
/ gene
/ Genes
/ Humans
/ Kinases
/ Migraine
/ Nitric Oxide Synthase Type III - genetics
/ Polymorphism, Genetic - genetics
/ Proteins
