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Clinical development of TargomiRs, a miRNA mimic-based treatment for patients with recurrent thoracic cancer

by van Zandwijk, Nico , Brahmbhatt, Himanshu , Pavlakis, Nick , MacDiarmid, Jennifer , Boyer, Michael , Reid, Glen , Kao, Steven C , Clarke, Stephen

in Apoptosis / Cancer / Cancer therapies / Cell cycle / Cell division / Cell growth / Clinical trials / Clinical Trials, Phase I as Topic / Drug resistance / EDVs / Gene expression / Humans / Lung cancer / Lung Neoplasms - therapy / malignant pleural mesothelioma / mesomiR-1 / Mesothelioma / Mesothelioma - therapy / Mesothelioma, Malignant / MicroRNAs / Minicells / miR-16 / miRNA / Patients / Post-transcription / Ribonucleic acid / RNA / RNAi Therapeutics - methods / Studies / targeted delivery / Therapy / Thoracic Neoplasms - therapy / Thorax / Tumors

2016

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Clinical development of TargomiRs, a miRNA mimic-based treatment for patients with recurrent thoracic cancer

by van Zandwijk, Nico , Brahmbhatt, Himanshu , Pavlakis, Nick , MacDiarmid, Jennifer , Boyer, Michael , Reid, Glen , Kao, Steven C , Clarke, Stephen

2016

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Clinical development of TargomiRs, a miRNA mimic-based treatment for patients with recurrent thoracic cancer

by van Zandwijk, Nico , Brahmbhatt, Himanshu , Pavlakis, Nick , MacDiarmid, Jennifer , Boyer, Michael , Reid, Glen , Kao, Steven C , Clarke, Stephen

2016

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Journal Article

Clinical development of TargomiRs, a miRNA mimic-based treatment for patients with recurrent thoracic cancer

van Zandwijk, Nico,

Brahmbhatt, Himanshu,

Pavlakis, Nick,

MacDiarmid, Jennifer,

Boyer, Michael,

Reid, Glen,

Kao, Steven C,

Clarke, Stephen

2016

Overview

miRNAs are responsible for post-transcriptional control of gene expression, and are frequently downregulated in cancer. It has become well established that restoring miRNA levels can inhibit tumor growth, and many studies have demonstrated this in preclinical models. This in turn has led to the first clinical trials of miRNA replacement therapy. This special report focuses on the development of TargomiRs - miRNA mimics delivered by targeted bacterial minicells - and the very first clinical experience of a miRNA replacement therapy in thoracic cancer patients in the Phase I MesomiR-1 trial.

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Publisher

Future Medicine Ltd

Subject

/ Cancer