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Cinnamomi Cortex (Cinnamomum verum) Suppresses Testosterone-induced Benign Prostatic Hyperplasia by Regulating 5α-reductase
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Cinnamomi Cortex (Cinnamomum verum) Suppresses Testosterone-induced Benign Prostatic Hyperplasia by Regulating 5α-reductase
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Journal Article
Cinnamomi Cortex (Cinnamomum verum) Suppresses Testosterone-induced Benign Prostatic Hyperplasia by Regulating 5α-reductase
2016
Overview
Cinnamomi cortex (dried bark of
Cinnamomum verum
) is an important drug in Traditional Korean Medicine used to improve blood circulation and Yang Qi. Benign prostatic hyperplasia (BPH) is a common chronic disease in aging men. This study was conducted to determine the effect of Cinnamomi cortex water extract (CC) on BPH. BPH was induced by a pre-4-week daily injection of testosterone propionate (TP). Six weeks of further injection with (a) vehicle, (b) TP, (c) TP + CC, (d) TP + finasteride (Fi) was carried on. As a result, the prostate weight and prostatic index of the CC treatment group were reduced. Histological changes including epithelial thickness and lumen area were recovered as normal by CC treatment. The protein expressions of prostate specific antigen, estrogen receptor α (ERα), androgen receptor (AR), 5α-reductase (5AR), and steroid receptor coactivator 1 were suppressed by treatment of CC. Immunohistochemical assays supported the western blot results, as the expressions of AR and ERα were down-regulated by CC treatment as well. Further
in vitro
experiments showed CC was able to inhibit proliferation of RWPE-1 cells by suppressing 5AR and AR. These results all together suggest CC as a potential treatment for BPH.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 82/80
/ Animals
/ Cell Proliferation - drug effects
/ Cholestenone 5 alpha-Reductase - metabolism
/ Cinnamomum zeylanicum - chemistry
/ Drugs, Chinese Herbal - pharmacology
/ Epithelial Cells - drug effects
/ Epithelial Cells - metabolism
/ Humanities and Social Sciences
/ Humans
/ Male
/ Prostatic Hyperplasia - chemically induced
/ Prostatic Hyperplasia - metabolism
/ Prostatic Hyperplasia - prevention & control
/ Receptors, Androgen - metabolism
/ Science
