Asset Details
Do you wish to reserve the book?
The olfactory deficits of depressed patients are restored after remission with venlafaxine treatment
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The olfactory deficits of depressed patients are restored after remission with venlafaxine treatment
Do you wish to request the book?
The olfactory deficits of depressed patients are restored after remission with venlafaxine treatment
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The olfactory deficits of depressed patients are restored after remission with venlafaxine treatment
2022
Overview
It is unclear whether olfactory deficits improve after remission in depressed patients. Therefore, we aimed to assess in drug-free patients the olfactory performance of patients with major depressive episodes (MDE) and its change after antidepressant treatment.
In the DEP-ARREST-CLIN study, 69 drug-free patients with a current MDE in the context of major depressive disorder (MDD) were assessed for their olfactory performances and depression severity, before and after 1 (M1) and 3 (M3) months of venlafaxine antidepressant treatment. They were compared to 32 age- and sex-matched healthy controls (HCs). Olfaction was assessed with a psychophysical test, the Sniffin' Sticks test (
:
score;
score;
:
score; total score:
+
+
= TDI score) and
(pleasantness score:
score; neutral score:
score; unpleasantness score:
score).
As compared to HCs, depressed patients had lower TDI olfactory scores [mean (s.d.) 30.0(4.5)
33.3(4.2),
< 0.001], T scores [5.6(2.6)
7.4(2.6),
< 0.01],
scores [7.5(3.0)
9.8(2.8),
< 0.001)] and higher
scores [3.5(2.6)
2.1(1.8),
< 0.01].
,
and
scores at baseline were independent from depression and anhedonia severity. After venlafaxine treatment, significant increases of
scores [M1: 7.0(2.6) and M3: 6.8(3.1),
< 0.01] and
scores [M1: 8.1(3.0) and M3: 8.4(3.3),
< 0.05] were evidenced, in remitters only (
:
< 0.01;
:
< 0.01). Olfaction improvement was mediated by depression improvement.
The olfactory signature of MDE is restored after venlafaxine treatment. This olfaction improvement is mediated by depression improvement.
Publisher
Cambridge University Press,Cambridge University Press (CUP)
Subject
