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Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis
by
Herbet, Mariola
, Walczak-Nowicka, Łucja Justyna
in
Acetylcholinesterase - chemistry
/ Alzheimer's disease
/ Animals
/ Apoptosis
/ Binding sites
/ Cell adhesion & migration
/ Cholinesterase Inhibitors - therapeutic use
/ Cytochrome
/ Enzymes
/ Humans
/ Hypotheses
/ Kinases
/ Ligands
/ Nervous system
/ Neurodegenerative diseases
/ Neurodegenerative Diseases - drug therapy
/ Neurodegenerative Diseases - enzymology
/ Neurodegenerative Diseases - pathology
/ Oxidative stress
/ Oxidative Stress - drug effects
/ Pathogenesis
/ Review
2021
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Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis
by
Herbet, Mariola
, Walczak-Nowicka, Łucja Justyna
in
Acetylcholinesterase - chemistry
/ Alzheimer's disease
/ Animals
/ Apoptosis
/ Binding sites
/ Cell adhesion & migration
/ Cholinesterase Inhibitors - therapeutic use
/ Cytochrome
/ Enzymes
/ Humans
/ Hypotheses
/ Kinases
/ Ligands
/ Nervous system
/ Neurodegenerative diseases
/ Neurodegenerative Diseases - drug therapy
/ Neurodegenerative Diseases - enzymology
/ Neurodegenerative Diseases - pathology
/ Oxidative stress
/ Oxidative Stress - drug effects
/ Pathogenesis
/ Review
2021
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Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis
by
Herbet, Mariola
, Walczak-Nowicka, Łucja Justyna
in
Acetylcholinesterase - chemistry
/ Alzheimer's disease
/ Animals
/ Apoptosis
/ Binding sites
/ Cell adhesion & migration
/ Cholinesterase Inhibitors - therapeutic use
/ Cytochrome
/ Enzymes
/ Humans
/ Hypotheses
/ Kinases
/ Ligands
/ Nervous system
/ Neurodegenerative diseases
/ Neurodegenerative Diseases - drug therapy
/ Neurodegenerative Diseases - enzymology
/ Neurodegenerative Diseases - pathology
/ Oxidative stress
/ Oxidative Stress - drug effects
/ Pathogenesis
/ Review
2021
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Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis
Journal Article
Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis
2021
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Overview
Acetylcholinesterase (AChE) plays an important role in the pathogenesis of neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative stress and aggregation of pathological proteins. There is a search for new compounds that can prevent the occurrence of neurodegenerative diseases and slow down their course. The aim of this review is to present the role of AChE in the pathomechanism of neurodegenerative diseases. In addition, this review aims to reveal the benefits of using AChE inhibitors to treat these diseases. The selected new AChE inhibitors were also assessed in terms of their potential use in the described disease entities. Designing and searching for new drugs targeting AChE may in the future allow the discovery of therapies that will be effective in the treatment of neurodegenerative diseases.
Publisher
MDPI AG,MDPI
Subject
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