Asset Details
Do you wish to reserve the book?
Effects of short‐term exercise on plasma metabolic and lipidomic profiles of individuals with type 2 diabetes
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Effects of short‐term exercise on plasma metabolic and lipidomic profiles of individuals with type 2 diabetes
Do you wish to request the book?
Effects of short‐term exercise on plasma metabolic and lipidomic profiles of individuals with type 2 diabetes
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Effects of short‐term exercise on plasma metabolic and lipidomic profiles of individuals with type 2 diabetes
2026
Overview
Type 2 diabetes mellitus (T2DM) is a common metabolic disorder characterized by chronic hyperglycaemia, with physical inactivity and excessive adiposity as predisposing factors. This clinical trial aimed to investigate the effects of an exercise intervention on the metabolome of T2DM participants, fasting and in response to an oral glucose tolerance test (OGTT) and an acute exercise stimulus. Thirteen people with T2DM (age 51 ± 7 years; body mass index 32.7 ± 4.9 kg/m2) completed 45 min of moderate‐intensity treadmill exercise on 12 days consecutively. Blood samples were collected before and after the first and last training sessions and during a pre‐ and postintervention OGTT. Fasted blood samples were collected from 198 healthy control subjects and 208 people with T2DM from an independent cohort for comparison. Samples were analysed using high‐resolution 1H nuclear magnetic resonance spectroscopy and liquid chromatography–mass spectrometry. The exercise intervention did not induce a shift towards a healthier fasted metabolome in people living with T2DM. In response to consumption of a glucose bolus (OGTT), glycolysis‐related metabolites increased and free fatty acids decreased, with no effect of the exercise intervention. In response to acute exercise, glucose and amino acids decreased and free fatty acids increased, with similar responses on the last day of training as on the first day, indicating no effect of the intervention. The clinical trial was registered prospectively in the Australian New Zealand Clinical Trials Registry ACTRN12617000286347 on 24 February 2017. What is the central question of this study? People with type 2 diabetes mellitus (T2DM) have a different metabolic phenotype and an impaired response to an oral glucose tolerance test compared with healthy individuals. It is unknown whether a short‐term exercise programme can improve this response. What is the main finding and its importance? Twelve consecutive days of moderate‐intensity exercise do not improve the fasted metabolic phenotype or oral glucose tolerance test response in people with T2DM. These findings suggest that exercise‐induced metabolic benefits in T2DM might occur only after longer‐term engagement in exercise activities.
Publisher
John Wiley & Sons, Inc,Wiley
Subject
/ Adult
/ Diabetes
/ Diabetes mellitus (non-insulin dependent)
/ Diabetes Mellitus, Type 2 - blood
/ Diabetes Mellitus, Type 2 - metabolism
/ Diabetes Mellitus, Type 2 - physiopathology
/ exercise
/ Fasting
/ Fatty Acids, Nonesterified - blood
/ Female
/ Glucose
/ Glucose Tolerance Test - methods
/ Humans
/ Magnetic resonance spectroscopy
/ Male
/ NMR
